Pengaruh variasi kadar pengisi laktosa dan manitol terhadap sifat fisik granul sebagai produk antara tablet effervescent ekstrak daun Senna (Cassia acutifolia)

Rahmayanti, Mayu ORCID: https://orcid.org/0000-0002-7356-1488 (2021) Pengaruh variasi kadar pengisi laktosa dan manitol terhadap sifat fisik granul sebagai produk antara tablet effervescent ekstrak daun Senna (Cassia acutifolia). Journal of Islamic Pharmacy, 6 (2). pp. 58-62. ISSN 2527-6123

Text 10176.pdf - Published Version Download (540kB)

Abstract

Senna leaf (Cassia acutifolia) is a plant that is widely known by the public to treat constipation. Senna leaf products have weaknesses in the form, taste and use irrational doses, so it needs to be formulated into pharmaceutical preparations with good quality, safety, and effectiveness. In pharmaceutical preparations, physical properties affect the quality of the preparations produced, both in intermediate and finished products. This study aims to determine the effect of variations in the levels of lactose and mannitol as filler on the physical properties of the effervescent granules of senna leaf extract. Effervescent granules were made using the melting method with a ratio of lactose and mannitol 25% : 75%, 50% : 50%, and 75% : 25%, while the extraction method for senna leaves used the infundation method with distilled water as a solvent. The effervescent granules obtained were tested for flow time, angle of repose, powder tapping and moisture content. The data obtained were analyzed by theoretical approach and statistical test using analysis of variance (ANOVA) with 95% confidence level. The results showed that the use of variations in the filler levels of lactose and mannitol with groups of 25% : 75%, 50% : 50%, and 75% : 25%, could affect the moisture content and angle of repose of the granules but had no effect on the compressibility and flow time of the granules. Mannitol with greater concentration increased the moisture content and angle of repose effervescent granules of senna leaf extract.

Item Type:	Journal Article
Keywords:	Cassia acutifolia; sennoside; laxative; effervescent granules; mannitol; lactose
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Mayu Rahmayanti
Date Deposited:	06 Apr 2022 13:53

Downloads

Origin of downloads

Actions (login required)

View Item