Formulation and characterization of SNEDDS of Dayak onion extract with comparative variation of surfactants, co-surfactants, and palm oil

Annisa, Rahmi, Firdausy, Alif Firman, Alawiyah, Ihda and Reformasiska, Farianda (2021) Formulation and characterization of SNEDDS of Dayak onion extract with comparative variation of surfactants, co-surfactants, and palm oil. Presented at International Pharmacy Ulul Albab Conference and Seminar (PLANAR), 31 Jul 2021, Malang.

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Abstract

Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a thermodynamically stable drug administration unitwith the capacityto increase the solubility of active pharmaceutical ingredients (API) and bioavailability. In addition, dayak onion extract is an active ingredient developed to increase the effectivenessof therapy. Theaims to formulate, characterize, and investigatestability. Moreover, the HLB approach was used to formulate SNEDDS from dayak onion extract, with a component ratioofpalm oil, a combination of surfactants (hydrophilic Tween 80, Tween 20) andlipophilic (Span 20 and Transcutol) and PEG 400 as co-surfactants. A total of sixty formulas were used, with an HLB range of 11-15and a ratio of 1:8:1, 1:7:2, and 2:7:1, followed by evaluating product characteristics. Furthermore, two formulas were selected, includingF13 (HLB 13) and F34 (HLB 14),atratios 1:8:1 and 1:7:2. The results showed particle size ranging from 10-200 nm,percent transmittance of <90%, while the viscosity and pH values were stable at various dilutions. Theevaluation for thermodynamicsindicates an unstable preparation. Therefore the SNEDDS formula of dayak onion extract using long-chain triglycerides (palm oil) was ineffective.

Item Type:	Conference (Paper)
Keywords:	SNEDDS; self-nano emulsification; characteristic test; palm oil; HLB; dayak onion (Eleutherinepalmifolia)
Subjects:	10 TECHNOLOGY > 1007 Nanotechnology
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Rahmi Annisa
Date Deposited:	25 Apr 2022 11:42

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