Serum IL-6/IL-10 ratio as a biomarker for the diagnosis and severity assessment of primary-open angle glaucoma

Rachmawati, Ermin ORCID: https://orcid.org/0000-0003-1045-7066, Rachma, Lailia Nur and Ulhaq, Zulvikar Syambani (2021) Serum IL-6/IL-10 ratio as a biomarker for the diagnosis and severity assessment of primary-open angle glaucoma. European Journal of Ophtalmology. pp. 1-6.

Text 10843.pdf - Published Version Restricted to Repository staff only Download (428kB)

Abstract

Objective:
To assess the performance of serum cytokine IL-6 and IL-6/IL-10 ratio as biomarkers for the diagnosis of primary open-angle glaucoma (POAG) and for determining its progression.
Methods:
In this study, 20 POAG patients and 21 healthy individuals from the Indonesian population were enrolled. The serum concentration of IL-6 and IL-10 were quantified. Comparative analysis was performed in addition to assessment of the diagnostic performance of cytokines using receiver-operating-curve (ROC) analysis.
Results:
POAG patients had a higher IL-6 (p < 0.0001) and IL-6/IL-10 ratio (p < 0.0001) than controls. Among the POAG subjects, advanced-stage patients exhibited a higher IL-6/IL-10 ratio than those in the early-moderate stage (p = 0.001; p = 0.006). The ROC curve analysis showed that both IL-6 level and IL-6/IL-10 ratio exhibited an excellent capability of diagnosing POAG (cut-off of 20.5 pg/mL (100% sensitivity and 94% specificity) and 4.4 (88% sensitivity and 94% specificity), respectively). Serum IL-6/IL-10 ratio displayed a better performance than IL-6 in discriminating POAG severity with cut-off of at least 6.6 (sensitivity of 86% and specificity of 90%) and 9.1 (sensitivity of 89% and specificity of 78%) classified according to C/D ratio and MD of VF, respectively.
Conclusion:
The balance between IL-6 and IL-10 serum levels is potentially useful in discriminating POAG severity.

Item Type:	Journal Article
Keywords:	cytokines; interleukin-6; interleukin-10; severity; disease progression; POAG
Divisions:	?? JDok ??
Depositing User:	dr Ermin rachmawati
Date Deposited:	14 Jun 2022 14:01

Downloads

Origin of downloads

Actions (login required)

View Item