The construction of matematical model for the mechanism of protein synthesis involving mTORC1 from the AMPK pathway

Kusumastuti, Ari, Jamhuri, Mohammad, Firdaus, Dewi and Hidayati, Nurul Anggraeni (2023) The construction of matematical model for the mechanism of protein synthesis involving mTORC1 from the AMPK pathway. IJCSAM (International Journal of Journal Computing Science and Applied Mathematics), 9 (1). pp. 21-27. ISSN 2477-5401

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Abstract

This study discusses the construction of mathematical models for the mechanism of protein synthesis involving the main regulator mTORC1 gene which is described in the singular pathway mTOR of the AMPK pathway. The genes in question include: AMPK, TSC2, Rheb, mTORC1 and S6K. The method used for this research is divided into two stages, namely pathway analysis for the mechanism of protein synthesis and the second is the formulation of mathematical models. Pathway analysis is performed as a reference in describing interactions in the form of kinetic reaction schemes. After the interaction scheme is created, it is then formulated into a mathematical model with the independent variable being time. Mathematical models for the mechanism of protein synthesis involving mTORC1 of the AMPK pathway in the form of ordinary time-dependent differential equations involving independent variables [TSC2], [pAMPK], [pTSC2], [Rheb^{GTP}], [Rheb^{GDP}], [mTORC1], [Raptor], [aRaptor], [Deptor], [PRAS40], [mTOR], [amTORC1], [mLST8], [S6K1] and [pS6K1].

Item Type:	Journal Article
Keywords:	Mathematical modelling; Protein Synthesis; Kinetic Reaction
Subjects:	01 MATHEMATICAL SCIENCES > 0102 Applied Mathematics
Divisions:	Faculty of Mathematics and Sciences > Department of Mathematics
Depositing User:	Ari Kusumastuti
Date Deposited:	14 Apr 2023 15:04

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