Potential inhibition of Melaleuca leucadendron L. compounds against the NSP5 SARS CoV-2 protein

Melani, Ira Resmi, Wafi, Muhammad Farid, Riandinata, Muhammad Reza, Halim, Putri Aulawiya Rosyida, Mutiah, Roihatul and Santosaningsih, Dewi (2022) Potential inhibition of Melaleuca leucadendron L. compounds against the NSP5 SARS CoV-2 protein. Indonesian Journal of Cancer Chemoprevention, 13 (3). pp. 195-206. ISSN 2355-8989

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Abstract

COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome (SARS-CoV-2), causing a global health emergency as a pandemic disease. The lack of certain drug molecules or treatment strategies to fight this disease makes it worse. Therefore, effective drug molecules are needed to fight COVID-19. Non Structural Protein (NSP5) or called Main Protease (Mpro) of SARS CoV 2, a key component of this viral replication, is considered a key target for anti-COVID-19 drug development. The purpose of this study is to determine whether the compounds in the Melaleuca leucadendron L. plant such as 1,8-cineole, terpene, guaiol, linalol, α-selinenol, β-eudesmol and γ-eudesmol are predicted to have antiviral activity for COVID-19. Interaction of compounds with NSP5 with PDB code 6WNP analyzed using molecular docking with Molegro Virtual Docker. Based on binding affinity, the highest potential as an anti-viral is Terpineol with binding energy (-119.743 kcal/mol). The results of the interaction showed that terpinol has similarities in all three amino acid residues namely Cys 145, Gly 143, and Glu 166 with remdesivir and native ligand. Melaleuca leucadendron L. may represent a potential herbal treatment to act as: COVID-19 NSP5, however these findings must be validated in vitro and in vivo.

Item Type:	Journal Article
Keywords:	COVID-19; in silico; NSP5/ 6WNP; Melaleuca leucadendron L.
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110804 Medical Virology 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Dr. M.Kes. Roihatul Muti'ah
Date Deposited:	05 May 2023 08:14

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