Formulation and physical stability test of red fruit oil (Pandanus conoideus Lam.) emulgel using carbopol 940 base as wound treatment

Inayatilah, Fidia Rizkiah, Mas’udah, Lailatul, Atmaja, Ria Ramadhani Dwi, Rahmayanti, Mayu ORCID: https://orcid.org/0000-0002-7356-1488, Ma’arif, Burhan and Sugihantoro, Hajar (2022) Formulation and physical stability test of red fruit oil (Pandanus conoideus Lam.) emulgel using carbopol 940 base as wound treatment. Biomedical & Pharmacology Journal, 15 (4). pp. 2357-2364.

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Abstract

Red fruit ( Lam.) contains high levels of fatty acids, α-tocopherol, and β-carotene which can accelerate wound healing. Red fruit oil (RFO) is formulated as an emulgel because it is comfortable to use, has high penetration, and has a low risk of irritation. Emulgel RFO must meet the standards for physical properties and stability of topical preparations.The purpose of this study was to determine the effect of variations in RFO concentration on the physical properties and physical stability of the RFO emulgel. Emulgel was made with various RFO concentrations of 5% w/v (F1), 10% w/v (F2), and 15% w/v (F3). Then there was a physical evaluation and tested for physical stability after storage for 28 days at room temperature (30ºC±2ºC). Variations in RFO concentration decreased dispersion and adhesion values in the evaluation of physical qualities. In the 28-day storage stability test, variations in RFO concentration decreased the pH value, dispersion and increased adhesion. Emulgel RFO before and after the cycling test did not change. After performing the mechanical test, all the RFO emulgels did not occur in phase separation. It can be concluded that the variation of RFO concentration affects the physical properties, namely, dispersion and adhesion. However, it did not affect the organoleptic, homogeneity, and pH of the emulgel. After 28-day storage, variations in RFO concentration significantly affected pH, spreadability, and adhesion, while homogeneity and organoleptic had no significant effect. Variations in RFO concentration did not affect the stability of the cycling test and mechanical test.

Item Type: Journal Article
Keywords: emulgel; formulation; physical properties; red fruit oil (Pandanus conoideus Lam.); stability
Subjects: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics
Divisions: Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User: Fidia Inayatilah
Date Deposited: 09 May 2023 10:40

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