The formulation of self-nanoemulsifying drug delivery system of ethanol extract of Marsilea crenata C. Presl. leaves

Ma'arif, Burhan ORCID: https://orcid.org/0000-0001-9182-343X, Tamara, Yuan, Al-Azzam, Faaza A. S., Azzahara, Rani, Rizki, Fahrul, Sugihantoro, Hajar, Maulina, Novia and Agil, Mangestuti (2023) The formulation of self-nanoemulsifying drug delivery system of ethanol extract of Marsilea crenata C. Presl. leaves. Rasayan Journal Chemistry, 16 (2). pp. 934-943. ISSN ISSN: 0974-1496 | e-ISSN: 0976-0083 |

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Abstract

Marsilea crenata C. Presl. contains phytoestrogens, which have structures or activity similar to estrogen and could
potentially be utilized as a neuroprotector in an estrogen deficiency disease. This study aims to utilize M. crenata in
the formulation of SNEDDS as a neuroprotector. The dosage form chosen aims to maintain stability and effectiveness
because of its multi-compound properties. M. crenata was extracted using ethanol, then formulated into four SNEDDS
formulas, and then characterization was done, which included physical quality (organoleptic and pH), particle size,
polydispersity index, transmittance percentage, and Scanning Electron Microscope (SEM) analysis. The results
showed that the four formulas produced a homogenous yellow color with a distinctive odor formulation; the values of
the pH, particle size, polydispersity index, and transmittance percentage were still in the allowable range; and the SEM
analysis showed that SNEDDS particles dominated with a spherical shape of particles. It can be concluded that the
ethanol extract of M. crenata leaves can be formulated into SNEDDS and the best SNEDDS formulation was formula
B at 100 ppm extract concentration which had the smallest particle size, smallest polydispersity index, and the largest
transmission percentage.

Item Type:	Journal Article
Keywords:	Green Clover, SNEDDS, Dosage Form Development, Characterization, SEM
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Burhan Ma'arif
Date Deposited:	05 Jun 2023 10:23

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