Prevention of Cytoadherence and Heart Cell Hypoxia of Balb/C Mices Infected with Plasmodium Berghei with Therapy of Pare (Momordica charantia L

Rahmah, Zainabur ORCID: https://orcid.org/0000-0003-0232-6891, Riskiyana, Riskiyana, Indriana, Nurfianti, Milliana, Alvi and Nashichuddin, Ach. ORCID: https://orcid.org/0009-0006-8273-8878 (2023) Prevention of Cytoadherence and Heart Cell Hypoxia of Balb/C Mices Infected with Plasmodium Berghei with Therapy of Pare (Momordica charantia L. Presented at Proceedings of the 12th International Conference on Green Technology (ICGT 2022), 17-18 Occtober 2022, Malang.

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Abstract

Background: Malaria is a disease caused by Plasmodium parasites (P. falciparum, P. ovale, P. vivax, P. malariae, P. knowlesi) infection often caused by the bite of female Anopheles mosquitoes which have Plasmodium parasites in their salivary glands. Plasmodium develops in the human liver and then invades red blood cells. This causes the symptoms of malaria. Cytoadherence is the adherence of erythrocytes infected by parasite on the endothelial surface of blood vessels due to mature parasites which causes adhesive molecules on the surface of erythrocytes to adhere with adhesive molecules on the endothelial surface of blood vessels. Causes of hypoxia in malaria include cytoadherence, sequestration, and anemia. Bitter melon (Momordica charantia L), which is a traditional medicine, contains terpenoid and alkaloid substances which have anti-malarial properties. There hasn’t been any study on the relationship between bitter melon and cytoadherence as well as hypoxia in malaria. Objective: To understand the effect of bitter melon therapy on decreasing cytoadherence and hypoxia in hepatocytes of Balb/c mice infected with Plasmodium berghei. Methods: This purely experimental research is conducted in vivo in a lab environment. There are 2 control groups, the positive control group which received anti-malarial therapy, and the negative control group which receives no therapeutic intervention. There are also 3 treatment groups, group 1 received a 4mg/gBW dose of bitter melon extract, group 2 received 8mg/gBW dose of bitter melon extract, and group 3 receive 12mg/gBW dose of bitter melon extract. Each group has 5 Balb/c mice infected with P. berghei. Results: There is a decrease in cytoadherence with a significant relationship (r = -0,917) and the most effective dose is 12mg/gBW. There is also a significant decrease in hypoxia with a significant relationship (r = -0,892) and the most effective dose is 12mg/gBW. Conclusion: Bitter melon therapy has a significant effect on decreasing cytoadherence and hypoxia in hepatocytes of Balb/c mice infected with P.berghei with the most significant dose of 12mg/gBW

Item Type:	Conference (Paper)
Keywords:	Malaria · cytoadherence · hypoxia · Momordica charantia L
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1118 Diseases > 111803 Parasitic Diseases > 11180313 Protozoan Infections
Depositing User:	Dr Zainabur Rahmah
Date Deposited:	14 Jun 2023 19:51

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