SNP (Single Nucleotide Polymorphism) at adiponectin gene in Type 2 Diabetes Mellitus (T2DM) patients

Punjungsari, Tyas Nyonita (2023) SNP (Single Nucleotide Polymorphism) at adiponectin gene in Type 2 Diabetes Mellitus (T2DM) patients. El-Hayah : Jurnal Biologi, 9 (2). pp. 48-54. ISSN 2657-0726

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Abstract

SNPs haplotype blocks can be used as genetic markers to trace particular diseases (means indirectly tracks the causative genes). One of the SNPs that affect disease is SNP positions 45 and 276. SNPs 45 and 276 in the APMI or ADIPOQ or Adiponectin that affect insulin production on T2DM patients. The aim of this research was to identify the presence of SNP 45 in patients with type 2 diabetes mellitus. Method of this research is descriptive exploration using type 2 diabetes mellitus patients in Gledug Village, Blitar Regency as specimen donors. Identification using DNA extraction, DNA Amplification, sequencing and bioinformatics analysis. The results of this project seven DNA extracted, the seven sequences have the same Qv20+ value as the sequence base pair, alignment analysis using blast, when compared with the adipoQ gene sequence with accession number NG_021140.1, it was found that the KT, SR and BP sequences had a 100% similarity level. Identification of candidate SNPs in the absence of the adenine nucleotide was found in the SR, KT, and ST sequences

Item Type:	Journal Article
Keywords:	ADIPOQ; SNP; T2D
Subjects:	06 BIOLOGICAL SCIENCES > 0604 Genetics > 060407 Genome Structure and Regulation 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060408 Genomics 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060409 Molecular Evolution
Divisions:	Faculty of Mathematics and Sciences > Department of Biology
Depositing User:	Tyas Nyonita Punjungsari
Date Deposited:	10 Aug 2023 12:36

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