Metabolite profiling of anticancer compounds in Saussure lappa based on UPLC-QToFMS/MS

Mutiah, Roihatul ORCID: https://orcid.org/0000-0002-8196-9029, Rachmawati, Ermin ORCID: https://orcid.org/0000-0003-1045-7066, Fitrianingsih, Avin Ainur and Zahiro, Syayida Roisatus (2023) Metabolite profiling of anticancer compounds in Saussure lappa based on UPLC-QToFMS/MS. Pharmacy Education, 23 (4). pp. 37-42. ISSN 1477-2701

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Abstract

Background: Saussure lappa is a plant of the Asteraceae family that has been known as a medicinal plant to treat cancer. However, there is still a lack of data about the metabolite profiling of this extract and target activity in the cancer signaling pathway.

Objective: This study aimed to identify metabolites and evaluate the anticancer activity of Saussure lappa active ingredients.

Method: The root sample was extracted using Ultrasound-Assisted Extraction (UAE) with 96% ethanol solvent. Evaluation of the anticancer activity of the compounds was carried out using the PASS SERVER tools.

Result: About 17 metabolites have been characterised. Interestingly, Saussureamine B, C, D, costunolide, and dehydrocostus lactone showed highly antineoplastic potential properties with several possible activities such as apoptosis agonists, MMP9 expression inhibitors, and Transcription factor NF-kappa B inhibitors.

Conclusion: The root extract of Saussure lappa is highly recommended to be developed as an anticancer drug candidate.

Item Type:	Journal Article
Keywords:	anticancer; metabolite profiling; Saussure lappa; UPLC-QToFMS/MS
Subjects:	03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Dr. M.Kes. Roihatul Muti'ah
Date Deposited:	11 Oct 2023 11:23

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