Analysis of antidiabetic potential of palmitic acid compounds through in silico activation

Salsabila, Ardellya Elfidaa, Susanti, Nurlaili ORCID: https://orcid.org/0000-0002-3799-2440 and Ulhaq, Zulvikar Syambani (2022) Analysis of antidiabetic potential of palmitic acid compounds through in silico activation. Presented at 2nd PLANAR : International Pharmacy Ulul Albab Conference & Seminar, 10 Aug 2022, Malang, Indonesia.

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Abstract

Diabetes Mellitus is a condition where the body's sugar level exceeds the blood's normal limit. Type 2 Diabetes Mellitus is the most common type of diabetes and is a chronic disease caused by insulin resistance and beta-cell dysfunction, resulting in decreased insulin sensitivity. The management of diabetes Mellitus is in the form of oral hypoglycemic drugs. Still, these drugs have side effects such as gastrointestinal disturbances, nausea, vomiting, hypoglycemia, macrovascular disorders, microvascular disorders, etc. So, it is necessary to seek alternative drugs to increase insulin sensitivity to lower blood sugar levels which are safer using herbal plants. One of the suspected plants that can be an alternative medicine to reduce excess blood sugar levels is the dandang gendis plant (Clinacanthus nutans). The dandang gendis plant (Clinacanthus nutans) contains palmitic acid, which can reduce excess blood sugar levels in the blood. This study aims to determine the potential of palmitic acid compounds from the Dandang gendis plant as an in silico AMPK protein activator. Qualitative descriptive method using molecular docking in silico method to determine the affinity and interaction with palmitic acid compounds in the dandang gendis plant in activating AMPK protein. Docking between palmitic acid and AMPK produces an energy value (ΔGbind) of -5.3 kcal/mol. docking of metformin resulted in the lowest energy value (ΔGbind) of 5.1 kcal/mol. The bond produced by palmitic acid docking has a fairly strong affinity for the AMPK protein of -5.3 kcal/mol. So palmitic acid, an ingredient in the dandang gendis plant (Clinacanthus nutans) has the potential as an antidiabetic.

Item Type:	Conference (Paper)
Keywords:	palmitic acid; AMPK; Dandang gendis plant (Clinacanthus nutans); antidiabetic; in silico
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Medical Education
Depositing User:	Nurlaili Susanti
Date Deposited:	02 Nov 2023 12:06

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