Standarisasi dan formulasi kapsul nanopartikel Qusthul Hindi (Saussurea Lappa) sebagai Obat Herbal Terstandar (OHT) untuk meminimalisir efek samping kemoterapi

Annisa, Rahmi ORCID: https://orcid.org/0000-0001-7536-5213, Anggraini, Wirda ORCID: https://orcid.org/0000-0002-9837-155X and Ardiani, Sela Standarisasi dan formulasi kapsul nanopartikel Qusthul Hindi (Saussurea Lappa) sebagai Obat Herbal Terstandar (OHT) untuk meminimalisir efek samping kemoterapi. Research Report. -, Malang. (Unpublished)

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Abstract

Nanotechnology is a science and technology that deals with the manipulation, processing, and utilization of materials at the nanometer scale, which is extremely small (around 1 to 100 nanometers). in this study, the researchers will develop a formulation for the standardization and downstream processing of Qusthul Hindi (Saussurea lappa) nanotechnology-based preparations as a chemopreventive agent to minimize chemotherapy side effects. This study employs a True Experimental Design followed by prototype development and scale-up production in the pharmaceutical industry. The Result showed the selected formulas using Miglyol 812, Tween 80, and PEG 400 components at concentrations of 2.13%, 5.81%, and 2.06% can be used for formulations (SNEDDS) qustul hindi (Saussurea lappa). The SNEDDS formula of qustul hindi (Saussurea lappa) extract provided in vitro release flux results that were 4.20 times higher in AGF media pH 1.2 ± 0.05, and 5.62 times higher in AIF media pH 6.8 ± 0, 05 compared with a solution of qustul hindi (Saussurea lappa) extract. The in vitro absorption results also showed a higher increase of 4.02 times in AGF media pH 1.2 ± 0.05 and 3.32 times higher in AIF media pH 6.8 ± 0.05 compared to the qustul hin

Item Type:	Research (Research Report)
Keywords:	Formula; Nanopartikel; Qusthul Hindi; SNEDDS
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Wirda Anggraini
Date Deposited:	22 Dec 2023 14:49

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