Effect of Annona muricata leaf extract on antioxidant activity and histology of the mamary tissue in the breast cancer model inVivo

Muchtaromah, Bayyinatul, Romaidi, Romaidi, Pratiwi, Kevin Heri and Rosyidah, Inayatur (2015) Effect of Annona muricata leaf extract on antioxidant activity and histology of the mamary tissue in the breast cancer model inVivo. Australian Journal of Basic and Applied Sciences, 7 (9). pp. 92-95. ISSN 1991-8178

Text (full text) 1807.pdf - Published Version Download (337kB)

Abstract

The utilization of medicinal plant for curing some degenerative illness such as breast cancer has gained attention during recent years due to their safety, effectivity and economic reason. However scientific data to prove these habit are still in limitation. This study aimed to determine the effect of ethanol extract of soursop (Annona muricata L.) leaves on levels of superoxide dismutase (SOD), Malondiadehyde (MDA) and histological section in the mammary tissue of breast cancer mice models. 20 animal model (mice) induced by 20 mg/kg bw of 7,12-Dimethilbenz (α) Antrasen (DMBA) were treated with extract of soursop leaves in various doses 0 (C+), 100 (T1), 150 (T2) and 200 mg/kg body weight (bw)/day (T3), while for negative control (C-) was only administrated with 0.5% CMC Na/day for 8 weeks and corn oil 2 times a week for 6 weeks. The effect of each treatment was analyzed by one-way ANOVA, and significant difference was analyzed by Duncan's multiple range test. The result revealed that soursop leaves extract with dose of 200 mg/kg bw increased the levels of SOD, and decreased the levels of MDA in mammary tissue and improved the mammary cells of breast cancer mice model close to normal conditions.

Item Type:	Journal Article
Keywords:	leaf extract; soursop; antioxidant; histology; breast cancer; mice
Subjects:	06 BIOLOGICAL SCIENCES > 0604 Genetics > 060499 Genetics not elsewhere classified
Divisions:	Faculty of Mathematics and Sciences > Department of Biology
Depositing User:	Bayyinatul Muchtaromah
Date Deposited:	18 Apr 2017 09:00

Downloads

Origin of downloads

Actions (login required)

View Item