Formulation and characterization of Eleutherine palmifolia Extraction in Carriers of Microspheres with variations in Chitosan Polymer Concentration

Mutiah, Roihatul ORCID: https://orcid.org/0000-0002-8196-9029, Humaidi, Edi, Rahmatullah, Muhammad Fahmi Yusral, Rahmawati, Ermin ORCID: https://orcid.org/0000-0003-1045-7066, Fitrianingsih, Avin Ainur ORCID: https://orcid.org/0000-0002-8196-9029 and Annisa, Rahmi ORCID: https://orcid.org/0000-0001-7536-5213 (2024) Formulation and characterization of Eleutherine palmifolia Extraction in Carriers of Microspheres with variations in Chitosan Polymer Concentration. Journal of Medicinal and Chemical Sciences, 7. pp. 649-659. ISSN 2651-4702

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Abstract

This study aims to determine the effect of variations in chitosan concentration as a polymer on the physical characteristics, mucoadhesive properties, and dissolution profiles of mucoadhesive tablets in carrier microspheres. Mucoadhesive tablets are made using the direct felt method. In making mucoadhesive tablets, three different concentrations of E. palmifolia extract compared to chitosan are used, including F1 (1:1), F2 (1:2), and F3 (1:3). Eleutherine palmifolia (L.) Merr is used as the active ingredient and chitosan is used as a polymer. Evaluation of the physical characteristics of mucoadhesive tablets includes tests for uniformity of content, size, hardness, brittleness, and crushing time. In addition, mucoadhesive properties are also evaluated, including expandability tests, wash-off tests, and dissolution tests. The measurement of content uniformity showed no significant difference from the three formulas with no significant difference (p > 0.606). The uniformity test results of size, hardness, brittleness, crushing time, and the wash-off test showed a significant difference by the significant difference in each test sequentially of 0.012, 0.018, 0.028, 0.000, and 0.004. Dissolution tests were carried out with simulated gastric fluid (SGF) pH 1.2 and simulated intestinal fluid (SIF) pH 6.8 dissolution media using a type 2 dissolution tester (paddle), and dissolution level measurements were carried out with UV-Vis spectrophotometer at a maximum wavelength of 340.5 nm. The dissolution values of the three mucoadhesive tablet formulas in simulated gastric fluid (SGF) pH 1.2 media and the median simulated intestinal fluid (SIF) pH 6.8 showed significant differences (p < 0.000).

Item Type:	Journal Article
Keywords:	E. palmifolia; Chitosan; Microspheres Tablets; Mucoadhesive Disolution
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Rahmi Annisa
Date Deposited:	05 Feb 2024 11:19

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