Compound Molecules of Network Pharmacology-Based of Tamarillo (Cyphomandra betacea Cav.) and the potential as noodle for type 2 Diabetes Mellitus Treatment

Fitriyani, Fitriyani, Ningrum, Salsabila E. S, Mutiah, Roihatul ORCID: https://orcid.org/0000-0002-8196-9029 and Kinasih, Larasati Sekar (2023) Compound Molecules of Network Pharmacology-Based of Tamarillo (Cyphomandra betacea Cav.) and the potential as noodle for type 2 Diabetes Mellitus Treatment. Traditional Medicine Journal, 28 (3). pp. 178-188. ISSN 2406-9086

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Abstract

Consuming noodles excessively is not good for health because it contains high trans fat, which can cause diabetes mellitus (DM) as a disease with a high prevalence, especially type 2 DM, as much as 95% in Indonesia. Tamarillo (Chypomandra betacea Cav.) can potentially reduce blood glucose levels and restore adipokine regulation to prevent insulin resistance in type 2 DM. This study aims to determine the formulation and potential of tamarillo compounds into noodle products named "Chypotes (Chypomandra Antidiabetes) Noodle" as an alternative food for type 2 DM patients. The methods used are noodle formulation, organoleptic test, hedonic test, and network pharmacology. Based on the results of an organoleptic test, Chypotes Noodle has a chewy texture, a distinctive smell, yellow colour, and a slightly sour tasteless taste typical of Tamarillo. Based on the results of the hedonic test, 30 respondents chose the like and very like options in filling out the questionnaire with a percentage of 80-90%. Based on the Network Pharmacology of Tamarillo shows that 150 of the 365 target proteins of Tamarillo are involved in the biological processes and signaling pathways of type 2 diabetes mellitus, with 75 target proteins locking and interacting. Compound Molecules of Tamarillo, such as six bioactive components of the hydroxycinnamic acids group, have activity in type 2 DM and affect the biological processes and signaling pathways of type 2 DM against ADIPOQ, TNF, and INS. Therefore, Tamarillo can potentially be used as an alternative food product in the form of noodles for type 2 DM treatment.

Item Type:	Journal Article
Keywords:	Chypotes Noodle; Hydroxycinnamic Acids; Network Pharmacology; Tamarillo; Type 2 DM
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Dr. M.Kes. Roihatul Muti'ah
Date Deposited:	15 Feb 2024 14:53

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