Laporan penelitian pengembangan System Penghantaran Obat Self Nanoemulsifying dalam Formulasi obat halal dan thayyib dengan pendekatan model Matematika menggunakan D-optimal design (sertifikat hak cipta)

Rahmi Annisa (2024) Laporan penelitian pengembangan System Penghantaran Obat Self Nanoemulsifying dalam Formulasi obat halal dan thayyib dengan pendekatan model Matematika menggunakan D-optimal design (sertifikat hak cipta). 000588741.

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Abstract

This study aims to develop a delivery system for the extract of E. palmifolia as a model of medicinal ingredients in SNEDDS using a D-optimal design approach.D-optimal mixture design optimises E. palmifolia loaded SNEDD by selecting SNEDDS composition as an independent factor (X) and characterizing SNEDDS as a response (Y). SNEDDS characterization in the optimal formula includes transmittance, emulsification time, pH, viscosity, particle size, and particle morphology. After obtaining one optimal formula, stability testing is carried out by comparing the initial characteristics (day one) with the characteristics of E. palmifolia loaded SNEDD. The SNEDDS was after storage for three months, namely day 30, day 60, and day 90. Miglyol 812, Tween 80, and polyethylenglycol (PEG) 400 were selected as oil, surfactant, and co- surfactant phases because they had the highest ability to dissolve E. palmifoliaextract.The formula design with the D-optimal mixture design approach formulated E. palmifolia loaded SNEDDS with Miglyol 812, Tween 80, and PEG 400 components at an oil concentration of 2.13%, surfactant 5.81%, and co-surfactant 2.06% with stable characteristics in the storage period of 3 months. Transmittance results in 96.75-98.74%, emulsification time 19.21-22.77 seconds, pH 6.69–7.71, viscosity 43.97-45.99 (cPs), particle size 19.14 - 22.19 nm, spherical particle morphology. The optimal formula for SNEDDS extract of E. palmifolia using the D-optimal design approach has physical and chemical characteristics that are in accordance with the SNEDDS specifications that have been determined.

Item Type:	Hak Cipta
Keywords:	D-optimal mixture design; E. palmifolia; self-nanoemulsifying; SNEDDS
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Rahmi Annisa
Date Deposited:	04 Apr 2024 10:02

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