The potential of red fruit oil emulgel (Pandanus conoideus Lamk.) in accelerate the proliferation phase of rat incision wound healing

Atmaja, Ria Ramadhani Dwi ORCID: https://orcid.org/0009-0004-5803-0744, Inayatilah, Fidia Rizkiah ORCID: https://orcid.org/0000-0001-7157-3760, Muktisari, Mawar Yuli ORCID: https://orcid.org/0009-0002-9329-1929, Ni'mah, Safa'atun ORCID: https://orcid.org/0009-0003-9426-5607 and Subandi, Imam ORCID: https://orcid.org/0000-0003-0115-0740 (2024) The potential of red fruit oil emulgel (Pandanus conoideus Lamk.) in accelerate the proliferation phase of rat incision wound healing. Journal of Medicinal and Pharmaceutical Chemistry Research, 6 (3). pp. 302-313. ISSN 29810213

Text 18887.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB)

Abstract

The plant known as Red fruit oil (Pandanus conoideus Lamk.) has the ability to accelerate wound healing. Red fruit oil contains compounds that are active in the healing process of incisional wounds, including tocopherols, carotenoids, oleic acid, linoleic acid, and linolenic acid. To enhance stability and penetration, red fruit oil was formulated in an emulsion form in this research. The aim of this study was to determine the activity of red fruit oil emulgel on collagen density and the amount of angiogenesis in incisional wound healing and to determine the optimal dose of red fruit oil emulgel on collagen density and the amount of angiogenesis in incisional wound healing. This research is a true experimental study that employs a post-test-only control group design with 6 treatment groups. ImageJ software is used to measure the percentage of collagen density area, while image raster software is used to measure angiogenesis. This study has shown that red fruit oil emulgel can enhance collagen production and angiogenesis in incisional wound healing. The optimal dose concentration of red fruit oil emulgel to increase collagen density and the amount of angiogenesis in incisional wound healing was shown in red fruit oil emulgel with a concentration of 15% w/v. The conclusion is that red fruit oil emulgel leads to an increase in collagen density and angiogenesis during wound healing in rat incisions

Item Type:	Journal Article
Keywords:	Rat; collagen density; angiogenesis; emulgel; incisions
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1110 Nursing > 111008 Nursing Practical 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111503 Clinical Pharmacy and Pharmacy Practice 11 MEDICAL AND HEALTH SCIENCES > 1116 Medical Physiology > 111603 Systems Physiology
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Ria Atmaja
Date Deposited:	08 May 2024 11:01

Downloads

Origin of downloads

Actions (login required)

View Item