The potential of 12 flavonoid compounds as alzheimer's inhibitors through an in silico approach

Gondokesumo, Marisca Evalina, Muslikh, Faisal Akhmal, Pratama, Rizki Rahmadi, Ma'arif, Burhan ORCID: https://orcid.org/0000-0001-9182-343X, Aryantini, Dyah, Alrayan, Reza and Luthfiana, Dewi (2024) The potential of 12 flavonoid compounds as alzheimer's inhibitors through an in silico approach. Journal of Medicinal and Pharmaceutical Chemistry Research. ISSN 2981-0213

Text JMPCR_Volume 6_Issue 1_Pages 50-61.pdf Download (1MB)

Abstract

Neurodegenerative disorders (NDD) are age-related condition characterized by a progressive decline in brain functions. This condition has influenced more than 8% of the adult population worldwide, predominately with Alzheimer's disease (AD). Currently, NDD treatment is addressed to relieve existing symptoms, so the effective medication is urgently needed. Flavonoids offer remarkable pharmacological properties applicable to be neuroprotective agents. This study aimed to determine the activity of flavonoid compounds against AD by inhibiting acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B) receptors. The method utilized molecular docking studies with the AutoDockTools 4.2.6 program. Analysis of pharmacochemical properties were carried out using SwissADME, while pharmacokinetics and toxicity were examined in the pkCSM web server. The results indicated that α-amyrin and pinoresinol were the most potential AChE and MAO-B inhibitor, respectively. The compounds have lower energy binding values, inhibition constants, and high percentage of similarity with amino acid residues in the ligand native. Analysis of the physicochemical and pharmacokinetic properties showed that these two compounds are acceptable to the body and provides no toxicity. This study demonstrated that the compounds α-amyrin and pinoresinol might potential to be therapeutic agent which primarily act to inhibit AChE and MAO-B in AD progression.

Item Type:	Journal Article
Keywords:	Aeration; AChE; alzheimer's disease; MAO-B; molecular docking; neurodegenerative disorders; flavonoid compounds
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Burhan Ma'arif
Date Deposited:	04 Jun 2024 15:09

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