Sweet flag (Acorus calamus L.) rhizomes chromatography column isolates potential as rich antioxidant compounds

Amalia, Suci ORCID: https://orcid.org/0000-0002-8656-8574, Fasya, A. Ghanaim ORCID: https://orcid.org/0000-0002-2273-4035, Dewi, Diana Candra ORCID: https://orcid.org/0009-0004-7008-3531 and Kadarani, Deva Krisna ORCID: https://orcid.org/0000-0002-5040-667X (2024) Sweet flag (Acorus calamus L.) rhizomes chromatography column isolates potential as rich antioxidant compounds. Indonesian Journal of Fundamental and Applied Chemistry, 9 (2). pp. 66-73. ISSN 2540-9409

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Abstract

Plant biodiversity in Indonesia is the prospective solution to overcome the top issues in the pharmacy sector, such as the unavailability of local materials in the purposing of independently manufacturing pharmaceutical products. One of plants that can be used for raw materials in the biopharmaceuticals is a sweet flag (Acorus calamus L.), which is rich in bioactive compounds such as flavonoids, alkaloids, phenolic compounds, tannins, steroids, saponins, glycosides, and terpenoids. Flavonoids are the majority bioactive compounds in sweet flag rhizomes, which leads this study to identify the flavonoids as antioxidant agents for biopharmaceutical product development later. This study determined the antioxidant activity of sweet flag rhizomes as its crude extract, ethyl acetate fraction, and column isolate. Based on phytochemical tests, column isolates were identified only to contain flavonoid compounds. Liquid chromatography Mass Spectrometry (LC-MS) in ethyl acetate fraction identified isorhamnetin, quercetin, kaempferol, genistein, and glycitein. Additionally, this study aims to show that column isolate has the highest purity level with the least inhibitory concentration of 50% (IC50) and the strongest antioxidant activity

Item Type:	Journal Article
Keywords:	Jeringau Rhizome; Acorus calamus; Column Isolate; Flavonoids; Antioxidants
Subjects:	03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030502 Natural Products Chemistry 03 CHEMICAL SCIENCES > 0301 Analytical Chemistry 03 CHEMICAL SCIENCES > 0305 Organic Chemistry
Divisions:	Faculty of Mathematics and Sciences > Department of Chemistry
Depositing User:	Mrs Suci Amalia
Date Deposited:	03 Jul 2024 14:28

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