Activity of antimalarial compounds from ethyl acetate fraction of sunflower leaves (Helianthus annuus L.) against Plasmodium falciparum parasites 3D7 strain

Mutiah, Roihatul, Badiah, Riadul and Hayati, Elok Kamilah (2017) Activity of antimalarial compounds from ethyl acetate fraction of sunflower leaves (Helianthus annuus L.) against Plasmodium falciparum parasites 3D7 strain. Asian Journal of Pharmacy and Technology, 7 (2). pp. 86-90. ISSN 2231-5713

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Abstract

Antimalarial study using methanol extract and ethyl acetate fraction of sunflower leaves had been done. The study was conducted to know antimalarial activity between methanol extract and ethyl acetate fraction at Plasmodium falciparum parasites 3D7 strain. Separation of compounds was done by maceration using methanol and partition using ethyl acetate. Identification of ethyl acetate fraction was done by using UPLC-MS instrument. The results shown ethyl acetate fraction obtained the highest peak based on database were artemisinin, heliangolide, linolenic acid, linoleic acid eupalinolide C. The results of antimalarial study shown that methanol extract had IC50 22.18 mg / mL, and ethyl acetate fraction had IC50 16.68 mg / mL. Antimalarial activity between methanol extract and ethyl acetate fraction showed no significant difference.

Item Type:	Journal Article
Keywords:	Sunflower leaves, Antimalarial, Plasmodium falciparum Strain 3D7, UPLC-MS
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110101 Medical Biochemistry - Amino Acids and Metabolites
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Dr. M.Kes. Roihatul Muti'ah
Date Deposited:	07 Aug 2017 09:25

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