Sinergism effect anticancer of etyl acetat fraction calotropis gigantea roots (eacgr) with 5 fluorouracil on human breast cancer T47D cell lines

Mutiah, Roihatul (2017) Sinergism effect anticancer of etyl acetat fraction calotropis gigantea roots (eacgr) with 5 fluorouracil on human breast cancer T47D cell lines. Presented at 7th International Conference on Green Technology, 5-6 October 2016, Universitas Islam Negeri Maulana Malik Ibrahim Malang. (Unpublished)

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Abstract

Objective: The objective of this study was to know the synergism effect of etyl acetat fraction Calotropis gigantea roots (EACGR) with 5 fluorouracil on human breast cancer t47d cell lines.

Methods: MTT assay was used to measure the growth inhibitory effect of the combination. Results: The data analysis showed that combination therapy of EACGR and 5 Fluorouracil have been synergistic effect at7 µg/ml EACGR and 32.5 µg/ml 5-FU, with Combination Index value (CI) ranging from 0.20 to 0.07. The effect minor synergistic of this combination was showed at dose 7 µg/ml EACGR and 62.5 µg/ml 5-FU, with Combination Index value (CI) ranging from 0.7 to 0.9.

Conclusion: Combination therapy of 7 µg/ml EACGR and 32.5 µg/ml 5-FU have been synergistic anticancer effect on human breast cancer cell line T47D.

Item Type:	Conference (Paper)
Keywords:	Calotropis gigantea; 5-FU; Human breast Cancer; Cell Lines T47D
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111201 Cancer Cell Biology
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Dr. M.Kes. Roihatul Muti'ah
Date Deposited:	07 Aug 2017 09:38

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