Comparison the anticancer effect of extract and fraction calotropis gigantea radix on human colon cancer WiDr and breast cancer t47d cell lines

Mutiah, Roihatul and Widyawaruyanti, Aty and Sukardiman, Sukardiman (2015) Comparison the anticancer effect of extract and fraction calotropis gigantea radix on human colon cancer WiDr and breast cancer t47d cell lines. Presented at 6th International Conference on Green Technology organized: Innovation in Islamic perspective for sustainable development action toward International Challenges;, 18-19 september 2015, UIN Malang. (Unpublished)

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Abstract

The anticancer effect of extract And fraction Calotropis gigantea radix on human colon cancer WiDr And Breast Cancer T47D Cell Lines have been evaluated. The ethanolic extract was fractionated gradually with dicloromethane (DCM), ethyl acetate (EA) and butanol (BuOH) to yield four fractions including DCM fraction, EA fraction, BuOH fraction and water fraction. The anticancer effect was performed using MTT method. The IC50 was used to express the anticancer potency. The result showed that extract and fraction of Calotropis gigantea radix have much more potent to colon cancer WiDr than breast cancer T47D cell lines. IC50 on WiDr cell lines were etanol extract (44,2 µg/ml), DCM fraction (14,92 µg/ml), EA fraction (1,25 µg/ml), BuOH fraction (1,12 µg/ml) dan water fraction (>1000 µg/ml). IC50 on T47D cell lines were etanol extract (89,75 µg/ml), DCM fraction (131,29 µg/ml), EA fraction (55,89 µg/ml), BuOH fraction (96,72 µg/ml), water fraction (>1000 µg/ml). DCM, EA and BuOH fractions are potential to be developed as an anticancer agent in colon cancer therapy.

Item Type: Conference (Paper)
Keywords: comparison; anticancer; Calotropis gigantea; WiDr cells; T47D cells
Subjects: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111205 Chemotherapy
Divisions: Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User: Dr. M.Kes. Roihatul Muti'ah
Date Deposited: 07 Aug 2017 02:29

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