Altered composition of the Indonesian gut microbiome and heavy metal resistance genes abundance in response to heavy metal exposure

Harjanti, Fitria Nungky, Khairunnisa, Maulida Aisyah, Wahyuono, Ruri Agung, Luqman, Arif and Wibowo, Anjar Tri (2024) Altered composition of the Indonesian gut microbiome and heavy metal resistance genes abundance in response to heavy metal exposure. Altered composition of the Indonesian gut microbiome and heavy metal resistance genes abundance in response to heavy metal exposure, 74 (1-4). pp. 79-96. ISSN 10.1504/IJEP.2024.10065024

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Abstract

Abstract: Exposure to heavy metals poses a significant risk to human health due to their accumulation through inhalation, ingestion, and contact with contaminants. Such exposure can profoundly alter the gut microbiome, potentially causing gastrointestinal disorders and heightened infection vulnerability. Indonesia, like other nations, grapples with heavy metal-related health issues. Nonetheless, the extent of heavy metal contamination in the Indonesian population and its impact on their gut microbiome remain unexplored. Our study aimed to evaluate heavy metal prevalence in stools from coastal and highland Indonesian populations and discern its potential effect on gut microbiome. We detected copper (Cu), barium (Ba), manganese (Mn), and zinc (Zn) in fecal samples, with notable concern regarding barium contamination (13 of 20 participants), known for its adverse health impacts. Genes linked to heavy metal resistance were widely distributed in both populations' stool samples, including znuC, nikE, modC, mntH, and arsB. Copper levels correlated negatively with Prevotella abundance, suggesting inhibition of its growth, while barium levels correlated positively with Prevotella, Faecalibacterium, and Ruminococcus abundance, indicating an antagonistic Ba-Cu relationship in shaping the microbiome.

Item Type:	Journal Article
Keywords:	Keywords: heavy metals; barium; metal resistance genes; gut microbiome
Subjects:	06 BIOLOGICAL SCIENCES > 0699 Other Biological Sciences > 069999 Biological Sciences not elsewhere classified
Divisions:	Faculty of Mathematics and Sciences > Department of Biology
Depositing User:	Fitria Nungky Harjanti
Date Deposited:	28 Oct 2024 09:29

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