Mechanism and antifungal activities vulvovaginal candidiasis isolated from patients against ethanol extracts of parameria laevigata (Juss.) moldenke stem bark

Anggraini, Wirda ORCID: https://orcid.org/0000-0002-9837-155X, Purwanto, Djoko Agus ORCID: https://orcid.org/0000-0002-2718-903X, Kusumawati, Idha ORCID: https://orcid.org/0000-0002-9451-3098 and Isnaeni, Isnaeni ORCID: https://orcid.org/0000-0003-4502-2433 (2024) Mechanism and antifungal activities vulvovaginal candidiasis isolated from patients against ethanol extracts of parameria laevigata (Juss.) moldenke stem bark. Pharmacognosy Journal. ISSN 09753575

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Abstract

Introduction: Fungal diseases are not an exception to the current antibiotic resistance situation. Antimicrobial stewardship programs and high drug screening are two of the measures that are being used. Today, fungal infections are severe health problems. Utilizing plant-based natural compounds that are effective against various human pathogenic fungi is one method for preventing the issues associated with fungal infection. In this research, extracts are used as an option to treat patients with Candida albicans infection. The research aimed to examine the antifungal properties of an ethanol extract from Parameria laevigata (Juss.) Moldenke stem bark against C. albicans isolated from patients. Methods: This research used a microdilution method. C. albicans from patients diagnosed with vulvovaginal candidiasis. The test sample is 70% and 96% ethanol extracted from P. laevigata stem bark. Data analysis used One-way ANOVA with a P value of 0.000. Results: The result showed that PLE-70 can inhibit the growth of C. albicans with the highest %inhibition for ATCC 14053, CP-1, CP-2, CP-3, and CP-4, respectively 36.39%; 37.51%; 38.66%; 45.78%; 84.87%. PLE-96 can inhibit the growth of C. albicans with the highest %inhibition for ATCC 14053, CP-1, CP-2, CP-3, and CP-4 respectively 17.49%; 17.77%; 29.27%; 34.12%; 38.42%. Conclusion: It was concluded that the ethanol extract from P. laevigata stem bark can inhibit C. albicans isolated from vulvovaginal candidiasis patients.

Item Type:	Journal Article
Keywords:	Candida albicans; Compound; Medicine; Microdilution method; Ultrasound Assisted Extraction
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Wirda Anggraini
Date Deposited:	30 Oct 2024 08:55

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