Exploring the potential of Tamarillo (Cyphomandra betacea Cav) compounds for the treatment of type 2 diabetes mellitus: A network pharmacology study

Mutiah, Roihatul ORCID: https://orcid.org/0000-0002-8196-9029, Fitriyani, Fitriyani, Ningrum, Salsabila E. S and Arriziq, Muhammad Abbas (2024) Exploring the potential of Tamarillo (Cyphomandra betacea Cav) compounds for the treatment of type 2 diabetes mellitus: A network pharmacology study. Tropical Journal of Natural Product Research, 8 (10). pp. 8704-8709. ISSN 2616-0692

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Abstract

The prevalence of diabetes mellitus (DM), especially type 2 DM, has been on the increase with a percentage of 95% in Indonesia. Tamarillo (Chypomandra betaceaCav.) can restore adipokine regulation and reduce blood glucose levels which prevents insulin resistance in type2 DM. Thus, this research aimed to explore the compounds and determine the molecular mechanism of Tamarillo on type 2 DM using a Network Pharmacology approach and compound exploration through a literature review. At the same time, the researchers determined the molecular mechanism using the Network Pharmacology approach: GeneCard, DisGeNET, STRING, Cytoscape, and KEGG database applications. The results showed that the multi-component compounds in Tamarillo had 150 out of 365 target proteins that work in biological processes and signalingpathways of type 2 DM, with 75 target proteins locked and interacting. Among the many molecules in Tamarillo, six bioactive components from the hydroxycinnamic acids group had activity on type 2 DM. These compounds affected biological processes in three types 2 DM signalingpathways: Adipocytokine, Insulin, and Glucagon signalingpathways. With the influence of hydroxycinnamic acid compounds on these three signalingpathways, Tamarillo had the potential to help lower blood glucose levels and prevent insulin resistance in type 2 DM patients. Therefore, Tamarillo fruit can be a safe and natural treatment alternative for patients with type 2 DM

Item Type:	Journal Article
Keywords:	Hydroxycinnamic Acids; Network Pharmacology; Tamarillo; Type 2 DM
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Dr. M.Kes. Roihatul Muti'ah
Date Deposited:	14 Nov 2024 09:24

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