Biosynthesis, characterization, and in-vitro anticancer effect of plant-mediated silver nanoparticles using Acalypha indica Linn: In-silico approach

Madaniyah, Luailik, Fiddaroini, Saidun, Hayati, Elok Kamilah, Sabarudin, Akhmad and Rahman, Moh. Farid (2025) Biosynthesis, characterization, and in-vitro anticancer effect of plant-mediated silver nanoparticles using Acalypha indica Linn: In-silico approach. OpenNano, 21 (1). pp. 1-28. ISSN 2352-9520

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Abstract

Cancer is a significant global health issue, with rising prevalence and mortality rates demanding
urgent attention. The World Health Organization emphasizes the need for effective prevention,
early detection, and treatment strategies to address this public health challenge. Current treatment modalities, including surgery, hormonal therapy, immunotherapy, radiation therapy, and
chemotherapy, are often associated with considerable side effects and high costs. This study investigates the biosynthesis of silver nanoparticles using Acalypha indica L. (AgNPs), a medicinal
plant recognized for its therapeutic benefits, as a potential cancer treatment with minimal side
effects and a lower risk of drug resistance. AgNPs exhibit anti-inflammatory properties and the
ability to inhibit angiogenesis while counteracting drug resistance mechanisms. Moreover, the use
of chitosan as a coating on AgNPs (AgNPs-Chit) enhances their stability and specificity toward
cancer cells, thereby improving their anticancer efficacy. Characterization of the synthesized
AgNPs was conducted using various techniques, including UV-Vis spectroscopy, X-ray diffraction
(XRD), Fourier-transform infrared spectroscopy (FTIR), particle size analysis (PSA), and transmission electron microscopy (TEM), confirming the successful synthesis, stability, and spherical
morphology of the nanoparticles, with an average diameter of 7 nm and a zeta potential of
− 24.51 mV. In vitro cytotoxicity testing showed that AgNPs-Chit exhibited stronger anticancer
activity against T47D cells with an IC50 value of 173 µg/mL, compared to AgNPs (IC50 244 µg/
mL) and the Acalypha indica L extract (IC50 826 µg/mL). When compared to the control, treatments with AgNPs-Chit, AgNPs, and the plant extract demonstrated statistically significant

Item Type:	Journal Article
Keywords:	Silver nanoparticles Acalypha Indica L. Chitosan Anticancer activity Molecular docking
Subjects:	03 CHEMICAL SCIENCES > 0301 Analytical Chemistry > 030101 Analytical Spectrometry 03 CHEMICAL SCIENCES > 0301 Analytical Chemistry 03 CHEMICAL SCIENCES > 0303 Macromolecular and Materials Chemistry
Divisions:	Faculty of Mathematics and Sciences > Department of Chemistry
Depositing User:	Elok Kamilah Hayati
Date Deposited:	04 Dec 2024 14:56

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