Protective role of Clinacanthus nutans against liver damage in streptozotocin-induced diabetic rats

Susanti, Nurlaili ORCID: https://orcid.org/0000-0002-3799-2440, Akbar, Putri Wulan, Suwondo, Aulia Sri Nastiti, Silahudin, Firdaus, Khafiralia, Mahasya, Reviansyah, Muhamad Daffa Abhista, Syukri, Nur Alqurratu A’yuni and Mashuri, Rasyidu Fabian (2024) Protective role of Clinacanthus nutans against liver damage in streptozotocin-induced diabetic rats. Malaysian Journal of Medicine and Health Sciences, 20 (6). pp. 19-24. ISSN 16758544

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Abstract

Diabetes mellitus (DM) triggers oxidative stress and damages many organs, including the liver. The development of herbal medicine is an important approach to preventing liver damage due to DM. This study investigated the effects of ethanolic extract of Clinacanthus nutans (EECN) on the liver anti-oxidant status and tissue morphology of diabetic rats. Materials and methods: Five groups of Male Wistar rats were comprised of healthy control rats (Group 1); untreated diabetic control rats (Group 2); diabetic rats given EECN 100 mg/kg BW (Group 3); diabetic rats given EECN 200 mg/kg BW (Group 4); and diabetic rats given EECN 400 mg/kg BW (Group 5). After 28 days of treatment, the rats were terminated. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations were measured from blood serum. Malondialdehyde (MDA) and Superoxide dismutase (SOD) levels were measured from liver tissue homogenates. Liver tissue was stained with Hematoxylin-Eosin and observed with a light microscope. Results: Serum ALT and AST, as well as liver MDA levels, decreased, while liver SOD levels increased in the EECN group compared to untreated diabetic rats. In addition, lower degenerative and necrotic changes in hepatocytes were also observed in the EECN group. Conclusion: EECN protects against liver tissue damage, as evidenced by reduced transaminases, oxidative stress, and degenerative hepatocytes.

Item Type:	Journal Article
Keywords:	Clinacanthus nutans; Diabetes; Liver damage; Oxidative stress; Transaminases
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics
Divisions:	Faculty of Medical and Health Sciences > Department of Medical Education
Depositing User:	Nurlaili Susanti
Date Deposited:	03 Dec 2024 14:33

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