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Gene targets with therapeutic potential in hepatocellular carcinoma

shodry, syifaus, Hasan, Yuliono Trika Nur, Ahdi, Iwal Reza and Ulhaq, Zulvikar Syambani (2024) Gene targets with therapeutic potential in hepatocellular carcinoma. World Journal of Gastrointestinal W J G O Oncology, 16 (12). pp. 4543-4547. ISSN 1948-5204

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Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Major treatments include liver transplantation, resection, and chemotherapy, but the 5-year recurrence rate remains high. Late diagnosis often
prevents surgical intervention, contributing to poor patient survival rates.
Carcinogenesis in HCC involves genetic alterations that drive the transformation of normal cells into malignant ones. Enhancer of zeste homolog 2 (EZH2), a key regulator of cell cycle progression, is frequently upregulated in HCC and is associated with advanced stages and poor prognosis, making it a potential biomarker. Additionally, signal transducer and activator of transcription 3, which binds to EZH2, affects disease staging and outcomes. Targeting EZH2 presents a promising therapeutic strategy. On the other hand, abnormal lipid metabolism is a hallmark of HCC and impacts prognosis. Fatty acid binding protein 5 is highly expressed in HCC tissues and correlates with key oncogenes, suggesting its potential as a biomarker. Other genes such as guanine monophosphate synthase, cell division cycle associated 5, and epidermal growth factor receptor provide
insights into the molecular mechanisms of HCC, offering potential as biomarkers and therapeutic targets.

Item Type: Journal Article
Keywords: Hepatocellular carcinoma; Enhancer of zeste homolog 2; Target genes; Biomarkers; Potential therapeutic
Subjects: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110307 Gastroenterology and Hepatology
Divisions: Faculty of Medical and Health Sciences > Department of Medical Education
Depositing User: YULIONO TRIKA NUR HASAN
Date Deposited: 05 Dec 2024 08:52

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