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Phytoestrogen Activity of Alkaloid Compounds of Butterfly Pea (Clitoria ternatea) Using In Silico Analysis

Fitriyah, Fitriyah (2024) Phytoestrogen Activity of Alkaloid Compounds of Butterfly Pea (Clitoria ternatea) Using In Silico Analysis. El Hayah: Jurnal Biologi, 9 (4). pp. 133-138. ISSN http://u.lipi.go.id/1438913086

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Abstract

Estrogen is a hormone involved in the development of sexual and reproductive characteristic, particullary in females. Estrogen is not only important for reproduction, but also in other systems such as the cardiovascular system, neuroendocrine system, immune system and muscoskeletal system in both men and women. The absence of estrogen during the menopause phase is a key factor contributing in the onset of cardiovascular disease. Phytoestrogens are polyphenolic and nonsteroidal compounds that have a structure and biological activity similar to 17β-estradiol
in humans. Most phytoestrogens are found in flavonoids, isoflavones and also alkaloids whose esterogenic potential has not been widely explored. Butterfly Pea (Clitoria ternatea) is a type of wild creeping plant from the Fabaceae family which contains number of active ingredients, including alkaloids. This research aims to determine the active compounds derived from Butterfly Pea (Clitoria ternatea) alkaloids which have the best potential as phytoestrogens using the in silico methods. A number of ligands which are active compounds derived from alkaloids in Butterfly Pea are linked to estrogen alpha as a receptor using molecular docking. The result of testing six alkaloid derivative compounds from Butterfly Pea indicate that Cephalotaxinone is the most effective candidate for phytoestrogenic use.

Item Type: Journal Article
Keywords: Alkaloid, Cllitoria ternatea, Fitoestrogen
Subjects: 06 BIOLOGICAL SCIENCES > 0699 Other Biological Sciences > 069999 Biological Sciences not elsewhere classified
Divisions: Faculty of Mathematics and Sciences > Department of Biology
Depositing User: Fitriyah Fitriyah
Date Deposited: 10 Dec 2024 08:41

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