The Effect of Binahong Leaf Gel (Anredera cordifolia) with the Addition of HPMC (Hydroxy Propyl Methyl Cellulose) on Wound Reduction and Angiogenesis in the Skin of Mice (Mus musculus) with Second-Degree Burns

Hartyastika, Silvi Ayuk and Holil, Kholifah (2023) The Effect of Binahong Leaf Gel (Anredera cordifolia) with the Addition of HPMC (Hydroxy Propyl Methyl Cellulose) on Wound Reduction and Angiogenesis in the Skin of Mice (Mus musculus) with Second-Degree Burns. El-Hayah. ISSN 2460-7207 (e), 2086-0064 (p)

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Abstract

Second-degree burn injury is a form of tissue damage to the skin and its
structure that can cause the risk of infection and hypovolemic shock, so
effective treatment is needed to accelerate healing and minimize long￾term impact. One of the medicinal plants that can be used to treat burn
injuries is the Binahong plant (Anredera cordifolia) which contains active
compounds that can increase the work of Vascular endothelial growth
Factor so as to increase angiogenesis. Therefore, this study aims to
determine the effect of binahong leaves with the addition of HPMC on
changes in wound area and angiogenesis. The type of research used in
this study is true experimental, which consists of 5 treatments, namely
negative control (K-, without ointment and binahong leaf extract gel),
positive control (K+, treated with bioplacenton ointment), treatment 1
(P1, treated with binahong leaf gel with 6.7 grams of extract), treatment
2 (P2, treated with binahong leaf gel with 8 grams of extract), and
treatment 3 (P3, treated with binahong leaf gel with 12 grams of extract).
Mice treated with various treatments were observed every 2 days until
day 14 to observe scab formation. Other parameters also observed in this
study were wound area narrowing and angiogenesis observed after
treatment. The data obtained were tested with ANOVA and continued
with LSD test at α 0.05. The results showed that binahong (Anredera
cordifolia) leaf gel with the addition of HPMC had an effect on wound
area narrowing and angiogenesis, with the most optimal results found in
P3 (binagong leaf gel with 12 grams of extract).

Item Type:	Journal Article
Keywords:	Angiogenesis Binahong gel Second degree burns Wound Constriction
Subjects:	06 BIOLOGICAL SCIENCES > 0608 Zoology > 060807 Animal Structure and Function
Divisions:	Faculty of Mathematics and Sciences > Department of Biology
Depositing User:	Kholifah Holil
Date Deposited:	05 Dec 2024 09:42

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