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The potency of lempuyang wangi (Zingiber zerumbet) as aldose reductase inhibitor: an alternative of anti-diabetes drugs

Minarno, Eko Budi ORCID: https://orcid.org/0000-0003-0793-4802 (2023) The potency of lempuyang wangi (Zingiber zerumbet) as aldose reductase inhibitor: an alternative of anti-diabetes drugs. Presented at 13th International Conference of Green Technology, 17-18 Oktober 2023, Malang, Indonesia.

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Abstract

Aldose reductase is an enzyme that plays a role in glucose metabolism. An increase
in aldose reductase will trigger an increase in blood sugar concentration by converting glucose
to sorbitol. Increased sorbitol conditions will result in diabetes complications such as diabetic
cataracts. So we need an inhibitor that can inhibit the working system of the aldose reductase
enzyme. One of the medicinal plants that has anti-diabetic properties is lempuyang wangi.
Lempuyang wangi has a secondary metabolite compound which has the potential as an anti�diabetic. The purpose of this study was to examine the anti-diabetic properties of lempuyang
wangi using the in silico method. In this research, docking was carried out with Pymol and
Pyrx software, and visualization using Biovia Discovery Studio to see the interaction between
zerumbone compounds and aldose reductase and compared with zopolrestat compounds. The
docking result of zopolrestat as a comparison compound is -9 kcal/mol, while xanthorrhizol
has a binding affinity value of -8,7 kcal/mol and has the same amino acid bonds with
zopolrestat, making it a potential candidate as an antidiabetic herbal drug in inhibiting the
working system of the aldose reductase enzyme

Item Type: Conference (Paper)
Keywords: lempuyang wangi (Zingiber zerumbet), anti-diabetes drugs
Subjects: 06 BIOLOGICAL SCIENCES > 0699 Other Biological Sciences > 069999 Biological Sciences not elsewhere classified
Divisions: Faculty of Mathematics and Sciences > Department of Biology
Depositing User: Eko Budi Minarno
Date Deposited: 17 Jan 2025 15:28

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