Phytochemical Assessment On N-Hexane Extract And Fractions Of Marsilea crenata Presl. Leaves Through GC-MS

Ma'arif, Burhan, Agil, Mangestuti and Laswati, Hening (2016) Phytochemical Assessment On N-Hexane Extract And Fractions Of Marsilea crenata Presl. Leaves Through GC-MS. Traditional Medicine Journal, 21 (2). pp. 77-85. ISSN 2406-9086

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Abstract

Estrogen deficiency causes various health problems in postmenopausal women, including osteoporosis. Phytoestrogen emerged as a potential alternative of estrogen with minimum side effects. Green clover (Marsilea crenata Presl.) is a typical plant in East Java which suspected contains estrogen-like substances. The aim of this research was to report the phytochemical properties of M. crenata using GC-MS as a preliminary study. M. crenata leaves were dried and extracted with n-hexane, then separated using vacuum column chromatography to get four fractions, after that the n-hexane extract and four fractions were identified with GC-MS. The results of GC-MS analysis showed some compounds contained in M. crenata leaves like monoterpenoid, diterpenoid, fatty acid compounds, and other unknown compounds. The results obtained in this research indicated a promising potential of M. crenata as medicinal plants, especially as antiosteoporotic agent.

Defisiensi estrogen menyebabkan berbagai masalah kesehatan pada wanita pascamenopause, salah satunya osteoporosis. Fitoestrogen muncul sebagai alternatif yang potensial pengganti estrogen dengan efek samping minimal. Semanggi (Marsilea crenata Presl.) merupakan tanaman khas Jawa Timur yang diduga mengandung senyawa dengan fungsi mirip estrogen (estrogen-like substances). Tujuan dari penelitian ini untuk melaporkan kandungan senyawa kimia dalam M. crenata menggunakan GC-MS sebagai studi pendahuluan. Daun M. crenata diekstraksi dengan n-heksana lalu dipisahkan menggunakan kromatografi kolom vakum, setelah itu ekstrak n-heksana dan empat fraksi yang didapatkan diidentifikasi menggunakan GC-MS. Hasil analisis GC-MS menunjukkan beberapa golongan senyawa yang terkandung dalam daun M. crenata seperti monoterpenoid, diterpenoid, senyawa asam lemak, dan senyawa lain yang belum diketahui. Hasil yang diperoleh dalam penelitian ini menunjukkan

Item Type:	Journal Article
Keywords:	Marsilea crenata Presl.; phytochemical; antiosteoporosis; GC-MS
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Burhan Ma'arif
Date Deposited:	19 Jan 2018 10:58

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