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DimensionsMadaniyah, Luailik, Fiddaroini, Saidun, Hayati, Elok Kamilah, Rahman, Farid and Sabarudin, Akhmad (2025) Stability of biologically synthesized silver nanoparticles (AgNPs) using Acalypha indica L. plant extract as bioreductor and their potential as anticancer agents against T47D cells. Science and Technology Indonesia, 10 (1). pp. 101-110. ISSN 2580-4391
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Abstract
This work investigates the anticancer potential of silver nanoparticles (AgNPs) against T47D cells as well as the stability of AgNPs manufactured using extract from Acalypha indica L. used as a bioreductant. The plant extract was used to produce and stabilize AgNPs, and stability was tracked for 30 days using UV-Vis spectroscopy and Particle Size Analysis (PSA), which included evaluations of extended sun exposure. Transmission Electron Microscopy (TEM) was used to characterize the size and shape of the nanoparticles, and Fourier Transform-Infrared Spectroscopy (FT-IR) was used to determine which functional groups were responsible for stabilization. Despite a gradual size increase, the AgNPs remained stable throughout the study period. The MTT assay confirmed their potent cytotoxicity against T47D cells, underscoring the potential of Acalypha indica-derived AgNPs as stable and effective agents for cancer therapy, offering a promising alternative for novel anticancer treatments.
| Item Type: | Journal Article |
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| Keywords: | Nanoparticle; Acalypha indica L; Plant Extract; Anticancer; Breast Cancer Cells |
| Subjects: | 03 CHEMICAL SCIENCES > 0301 Analytical Chemistry |
| Divisions: | Faculty of Mathematics and Sciences > Department of Chemistry |
| Depositing User: | Elok Kamilah Hayati |
| Date Deposited: | 06 Feb 2025 13:52 |
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