Potential of Clinacanthus nutans in the treatment of diabetes mellitus and molecular mechanisms prediction based on network pharmacology

Susanti, Nurlaili ORCID: https://orcid.org/0000-0002-3799-2440, Mustika, Arifa and Khotib, Junaidi (2025) Potential of Clinacanthus nutans in the treatment of diabetes mellitus and molecular mechanisms prediction based on network pharmacology. Presented at The 5th International Conference on Life Science and Technology (ICoLiST), Malang.

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Abstract

Clinacanthus nutans is rich in phytoconstituents and is considered a promising medicinal plant. This study aims to review the potential of C. nutans as an anti-diabetic and to explore its molecular mechanism based on network pharmacology. A literature review was conducted on articles, obtained from Scopus and Google Scholar databases, showed that C. nutans has an anti-diabetic effect. For network pharmacology analysis, the bioactive compounds of C. nutans were acquired from previous related research and SwissADME was used to predict its Drug-likeness based on Lipinski rule and oral bioavailability score. The overlapping between diabetes-associated genes, retrieved by DisGeNET database, and the predicted C. nutans target genes were visualized by Venn Diagram. Protein-protein interaction networks of these overlapping genes were identified using String-db. These interactions form a PPI network, which is subsequently evaluated by Cytoscape 3.9.1 software to analyze potential genes and then used to construct a compound-target network. Finally, the signaling pathways involved in these genes were analyzed based on the KEGG database. These results imply that C. nutans has potential as anti-diabetic through several signaling pathways associated with diabetes mellitus. This provides a scientific basis for further research on the anti-diabetic mechanism of C. nutans.

Item Type:	Conference (Paper)
Keywords:	Bioactive compounds; Clinacanthus nutans; Diabetes Mellitus; Network Pharmacology
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Divisions:	Faculty of Medical and Health Sciences > Department of Medical Education
Depositing User:	Nurlaili Susanti
Date Deposited:	07 Feb 2025 08:53

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