Spanlastic as a transdermal drug delivery system: A systematic review

Annisa, Rahmi ORCID: https://orcid.org/0000-0001-7536-5213 (2025) Spanlastic as a transdermal drug delivery system: A systematic review. Biomedical and Pharmacology Journal, 18 (1). pp. 447-457. ISSN 2456–2610

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Abstract

Spanlastic is an innovative drug delivery system that traps drugs in a core cavity with a double-layer structure. The term spanlastic comes from the combination of Span and elastic, first introduced in 2011. This plastic is a development of liposomes and niosomes that have been modified sophisticatedly; several types of spanlastic include Multi Lamellar Vesicles (MLV) with a bilayer structure, size 0.5-1.0 microns, easy to make, frequently used, and long-term stable. Large Unilamellar Vesicles (LUV) measuring 100 nm-1 μm have a high water or lipid ratio and can accommodate more drugs; Small Unilamellar Vesicles (SUV) measuring 20 nm-50 μm, prepared from MLV by sonication. The growing interest in spanlastics for various administrative strategies has been evident. These nanovesicles, composed of a surfactant, are highly elastic and adaptable, encapsulating an aqueous solute solution. Studies have shown that spanlastics exhibit greater chemical stability and address several limitations of conventional dosage forms. They enhance drug delivery by enabling targeted distribution and controlled release of natural medicinal components, among other advantages. Spanlastics overcome many challenges associated with traditional drug formulations by facilitating the precise delivery of active pharmaceutical ingredients and regulating their release rate. This review highlights their significance, penetration mechanism, preparation methods, and applications.

Item Type:	Journal Article
Keywords:	Edge Activators; Nanocarrier; Nanovesicles; Penetration; Spanlastics; Transdermal
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Rahmi Annisa
Date Deposited:	22 Apr 2025 08:37

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