Green synthesis of nanoparticles using cottonwood and rambutan honeys: Optimization, characterization, and enhanced antioxidant activity with reduced toxicity via oligochitosan coating

Fiddaroini, Saidun, Prisilia, Friske, Karo, Silvana, Madaniyah, Luailik, Khairana, Almas Dwi, Rahmaniah, Galuh, Amalia, Suci ORCID: https://orcid.org/0000-0002-8656-8574, Aulanni’am, Aulanni’am, Rahman, Moh Farid, Dinira, Layta, Fardiyah, Qonitah and Sabarudin, Akhmad (2025) Green synthesis of nanoparticles using cottonwood and rambutan honeys: Optimization, characterization, and enhanced antioxidant activity with reduced toxicity via oligochitosan coating. Next Materials, 8 (100685). ISSN 29498228

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Abstract

The green synthesis of silver nanoparticles (AgNPs) using bio-based reductants has gained significant attention due to its environmentally friendly and sustainable approach. This study aims to optimize the synthesis, characterize the physicochemical properties, and evaluate the biological activities of AgNPs synthesized using cottonwood (Ceiba pentandra) and rambutan (Nephelium lappaceum) honeys as bioreducing agents, with further functionalization by oligochitosan to enhance stability and bioactivity. Comprehensive characterization using UV-Vis spectroscopy, FTIR, PSA-DLS TEM, FESEM-EDX, and XRD confirmed the formation of spherical nanoparticles with an average size of 9.01 nm. The particle size distribution followed a lognormal model with an R² value of 0.925, indicating high statistical reliability. The biological activities of AgNPs and AgNPs-Ch composites were evaluated through antioxidant and toxicity assays. The DPPH assay demonstrated a 3.00–3.41-fold enhancement in antioxidant activity upon chitosan coating, suggesting a synergistic interaction between AgNPs and oligochitosan in free radical scavenging. Furthermore, toxicity assessment using Artemia salina nauplii revealed a substantial 6.12–6.19-fold reduction in toxicity for AgNPs-Ch compared to uncoated AgNPs, highlighting the protective role of chitosan in mitigating silver ion release. These findings underscore the potential of honey-derived AgNPs and their chitosan composites for biomedical and environmental applications, providing a sustainable route for nanoparticle synthesis with improved biofunctionality and safety.

Item Type:	Journal Article
Keywords:	Silver nanoparticle; Oligochitosan; Honey; Antioxidant; Toxicity
Subjects:	03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030201 Bioinorganic Chemistry 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030204 Main Group Metal Chemistry 03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030504 Organic Green Chemistry 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry
Divisions:	Faculty of Mathematics and Sciences > Department of Chemistry
Depositing User:	Mrs Suci Amalia
Date Deposited:	06 May 2025 13:05

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