Effect of ethanol extract from kepel leaves (Stelechocarpus Burahol (Bl.) Hook F. & Th.) on confluence and viability of primary mouse (Mus musculus) neuronal cells

Harjanti, Fitria Nungky ORCID: https://orcid.org/0000-0003-0971-108X and Hanifah, Lil (2025) Effect of ethanol extract from kepel leaves (Stelechocarpus Burahol (Bl.) Hook F. & Th.) on confluence and viability of primary mouse (Mus musculus) neuronal cells. El-Hayah: Jurnal Biologi, 10 (2). pp. 83-87. ISSN 2657-0726

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Abstract

Kepel (Stelechocarpus Burahol (Bl.) Hook F. & Th.), a plant indigenous to Indonesia, is popular for its various benefits, including anti-hyperuricemia, xanthine oxidase inhibition, anti-implantation, anticancer, antiseptic, anti inflammatory, and antioxidant properties. However, its potential as a neuroprotective agent is not well understood. Therefore, this study aims to investigate the confluence and viability of primary mouse neurons following the administration of ethanol extract from Kepel (Stelechocarpus burahol (Bl.) Hook F. & Th.) leaves. Primary neuron cell cultures were divided into four treatment groups: NT (without treatment) as a control group, T1 (50 µL of Kepel leaf extract), T2 (75 µL of Kepel leaf extract), and T3 (100 µL of Kepel leaf extract). After 48 hours of incubation, culture confluence and viability were assessed. This study approved that the ethanol extract of Kepel leaves did not significantly affect confluence compared to the control, but cell viability increased when treated with the Kepel leaf extract compared to the control.

Item Type:	Journal Article
Keywords:	Stelechocarpus Burahol; primary neuron; confluence; viability
Subjects:	06 BIOLOGICAL SCIENCES > 0608 Zoology > 060805 Animal Neurobiology
Divisions:	Faculty of Mathematics and Sciences > Department of Biology
Depositing User:	Fitria Nungky Harjanti
Date Deposited:	29 Jul 2025 10:02

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