From ethnomedicine to potential herbal product: Standardization of Uvaria rufa blume bark

Ma'arif, Burhan ORCID: https://orcid.org/0000-0001-9182-343X, Taek, Maximus M., 'Aini, Zakiya Q., Rahmayanti, Mayu ORCID: https://orcid.org/0000-0002-7356-1488, Maulina, Novia and Iskandar, Helmi S. (2025) From ethnomedicine to potential herbal product: Standardization of Uvaria rufa blume bark. Presented at INTERNATIONAL CONFERENCE ON SUSTAINABLE NATURAL PRODUCTS IN HEALTHCARE (ICSNPH): “Interdisciplinary Approaches from Lab to Clinical Breakthroughs”, 13 June, 2025, Sanata Dharma University.

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Abstract

Uvaria rufa Blume, locally known as lelak, is an ethnomedicinal plant traditionally used in East Nusa Tenggara, Indonesia, to treat conditions such as fever, bleeding, and skin allergies. To support its development as a raw material for herbal medicines, standardization is crucial to ensure its safety, efficacy, and quality. This study aimed to establish a standardization profile to ensure the consistent quality of U. rufa bark sourced from East Nusa Tenggara. A descriptive experimental method was used to determine specific and non-specific parameters of the bark. Specific parameters included identification of the plant part (bark), macroscopic characteristics (8–10 cm long, dark brown exterior, yellow interior, fibrous texture), microscopic features (parenchyma with stone cells, sclerenchyma, cork tissue), and organoleptic properties (light brown color, slightly astringent, aromatic, fine powder). The water-soluble extractive value was 12.0160% ± 0.0090, and ethanol-soluble was 22.475% ± 0.0111. Non-specific parameters assessed safety and stability: loss on drying (7.26% ± 0.8723), moisture content (9.4% ± 0.2000), total ash content (2.601% ± 0.0002), and heavy metal levels (Pb: 0.0472 ppm, Cd: 0.0014 ppm). All results met the general requirements for herbal standardization, supporting U. rufa bark’s potential as a standardized herbal medicine ingredient.

Item Type:	Conference (Paper)
Keywords:	East nusa tenggara; ethnomedicine; standardization; Uvaria rufa blume
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Burhan Ma'arif
Date Deposited:	09 Sep 2025 10:11

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