Optimization of Liquid Shampoo Formula from Chia Seed Oil (Salvia hispanica L) Using the Simplex Lattice Design Method

Rahmayanti, Mayu ORCID: https://orcid.org/0000-0002-7356-1488, Amalina, Faidatul, Afrizal, Muhammad, Nastiti, Ginanjar Putri ORCID: https://orcid.org/0009-0003-8468-9385 and Syarifuddin, Sadli ORCID: https://orcid.org/0009-0006-9045-5739 (2024) Optimization of Liquid Shampoo Formula from Chia Seed Oil (Salvia hispanica L) Using the Simplex Lattice Design Method. Media Farmasi: Jurnal Ilmu Farmasi (Journal of Pharmaceutical Science), 21 (2). pp. 53-62. ISSN e-ISSN 2503-5223

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Abstract

Hair loss is a common concern affecting both men and women, with various factors contributing to this condition. Chia plants are known to contain agents that stimulate sebaceous glands, which are crucial for promoting hair follicle growth and preventing hair loss, due to their keratin protein concentration of 23%. This study aimed to determine the optimal formulation of a liquid shampoo using Design Expert software, focusing on the physical characteristics and stability of the product. The optimization process involved two key components: Hydroxypropyl Methylcellulose (HPMC) and Sodium Lauryl Sulfate (SLS), with viscosity and foam height as the primary responses. The optimal formulation was identified through the software, followed by a series of characteristic and stability tests. Stability was assessed using a cycling test, where the shampoo was stored at 4°C and 40°C for 48 hours. The results indicated an optimal formula with component concentrations of X1 at 0.589307% and X2 at 9.41069%. Statistical analysis using a one-sample t-test revealed no significant differences in viscosity and foam height (p > 0.05). The physical characteristics of the optimal formula met acceptable standards, exhibiting organoleptic properties, homogeneity, viscosity of 414.80 ± 9.94 cPs, foam height of 7.060 ± 0.11 cm, and a pH of 7.39 ± 0. These findings suggest that the optimized shampoo formulation can effectively support hair health and prevent hair loss, providing a promising option for consumers seeking effective hair care solutions.

Item Type:	Journal Article
Keywords:	Chia seed oil Liquid shampoo Simplex Lattice Design
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Mayu Rahmayanti
Date Deposited:	28 Nov 2025 17:00

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