The anti-adhesion activity of Aspergillus oryzae cell free supernatant prevents the formation of Klebsiella pneumoniae biofilms on abiotic surfaces

Rachma, Lailia Nur ORCID: https://orcid.org/0000-0003-0199-9656, Raras, Tri Yudani Mardining ORCID: https://orcid.org/0000-0002-6881-2676, Fitri, Loeki Enggar ORCID: https://orcid.org/0000-0002-4880-1048 and Prawiro, Sumarno Reto (2022) The anti-adhesion activity of Aspergillus oryzae cell free supernatant prevents the formation of Klebsiella pneumoniae biofilms on abiotic surfaces. NeuroQuantology, 20 (6). pp. 4821-4828. ISSN 1303-5150

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Abstract

For more than a century, humans have used medical equipment. While very helpful in treating patients, they can cause serious health problems. The spread of bacteria through indwelling medical devices is the beginning of the problem. Adhesion to the medical device's surface then proceeds with forming a biofilm. This structure then becomes a reservoir of resistant bacteria. The purpose of this study was to investigate the potential of the Aspergillus oryzae in inhibiting biofilm and bacterial adhesion to abiotic polystyrene surfaces. We used A. oryzae cell-free supernatant (CFSAO) to challenge Klebsiella pneumoniae (ATCC1705). We studied the potential of CFSAO in inhibiting growth, adhesion, and production of Klebsiella pneumoniae biofilm. The cell-free supernatant of A. oryzae was proven to have bactericidal activity against K. pneumoniae. Cell-free supernatant A. oryzae was able to inhibit the adhesion of K. pneumoniae to abiotic surfaces. In addition, CFSAO firmly controls Klebsiella pneumoniae biofilm formation. In addition, CFSAO was able to destroy K. pneumoniae biofilms that had formed. Together, these results explain that A. oryzae can be used as natural antiadhesive coatings to prevent the colonization of medical devices

Item Type:	Journal Article
Keywords:	anti-adhesion; Aspergillus oryzae cell; supernatant prevents; Klebsiella pneumoniae
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110801 Medical Bacteriology
Divisions:	Faculty of Medical and Health Sciences > Department of Medical Education
Depositing User:	Lailia Rachma
Date Deposited:	31 Dec 2025 21:21

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