Design, Formulation, and Evaluation of Vitamin C Tablets Using Co-Processed Excipient Combination of Jackfruit Seed Starch and Avicel®️ PH 101

Rahmayanti, Mayu ORCID: https://orcid.org/0000-0002-7356-1488, Dewi, Tanaya Jati Dharma, Aktifa, Ana Fadilia, Paramitha, Sella, Nikmah, Rahayu Hikmatul and Septianshar, Lumen Muzaidi (2025) Design, Formulation, and Evaluation of Vitamin C Tablets Using Co-Processed Excipient Combination of Jackfruit Seed Starch and Avicel®️ PH 101. Jurnal Farmasi Sains dan Komunitas (JFSK), 22 (2). pp. 229-238. ISSN 2527-7146

Text (S2) Rahmayanti et al.pdf Download (376kB)

Abstract

Tablet is a popular pharmaceutical dosage form among the public. One
method of making tablets is direct compression. This method must
consider the flow properties and compressibility of the excipients. But
many excipients do not meet these criteria, leading to the alternative
use of co-processed excipients of jackfruit seed starch and avicel®️ PH
101. This research aims to determine the physical characteristics of
direct compression vitamin C tablets using co-processed excipient of
PBN-A (Jackfruit Seed Starch and Avicel®️ PH 101) with varying ratios
of 1:3, 3:1, and 1:1. The research methods include powder preparation,
powder evaluation, tablet compression, and physical evaluation of
tablet. Descriptive and statistical data analysis using one-way ANOVA.
The research results show that tablets exhibit favorable physical
characteristics in F1, but F2 and F3 show suboptimal hardness and
friability values. The statistical analysis results indicate a significant
difference with a p-value of (0.000) and post-hoc tests explain that
these significant differences are particularly noticeable between F1
and F2, K1, and K2. This study concludes that vitamin C tablets using
co-processed excipients of PBN-A with ratios of 1:3, 3:1, and 1:1 exhibit good physical characteristics in all evaluations, except for the hardness and friability of F2 (3:1) and the hardness of F3 (1:1).

Item Type:	Journal Article
Keywords:	Co-processed excipient; Direct compression; Filler agent; Tablet; Tabletting method
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Mayu Rahmayanti
Date Deposited:	06 Jan 2026 08:30

Downloads

Origin of downloads

Actions (login required)

View Item