Tripolar electrical stimulation as a potential modulator of metabolic and hematological profiles in mice

Tirono, Mokhamad ORCID: https://orcid.org/0000-0001-8933-4725 and Syihabuddin, Thilal ORCID: https://orcid.org/0000-0001-9963-9370 (2026) Tripolar electrical stimulation as a potential modulator of metabolic and hematological profiles in mice. Applied Biological Research, 28 (1). pp. 130-139. ISSN 0974-4517

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Abstract

Elevated blood cholesterol and glucose levels are common conditions among the elderly, often requiring continuous pharmacological intervention. To explore alternative approaches, the present study investigated the effects of alternating electrical simulation on these parameters, as well as on hemoglobin concentration and blood viscosity, using mice as experimental subjects. Treatment were applied at voltages ranging from 0 to 2.0 V, with a frequency of 500 kHz, for durations of 3 or 5 minutes per day over a 5-day period. The results revealed that electric stimulation at 2.0 V for 5 minutes reduced cholesterol levels by 7.53-9.0% and glucose levels by 28.41%, while hemoglobin levels tended to increase without a consistent pattern. Blood viscosity decreased under stimulation at 1.0 and 1.5 V but increased at 2.0 V, indicating a voltage-dependent response. In conclusion, electrical stimulation effectively lowered cholesterol and glucose levels in mice; however, its effects on hemoglobin and blood viscosity were non-linear, suggesting the need for further studies to optimize treatment parameters.

Item Type:	Journal Article
Keywords:	frequency, glucose, mice, tripolar, voltage
Subjects:	02 PHYSICAL SCIENCES > 0299 Other Physical Sciences > 029901 Biological Physics
Divisions:	Faculty of Mathematics and Sciences > Department of Physics
Depositing User:	Dr. Mokhamad Tirono
Date Deposited:	02 Jun 2026 09:22

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