Boron Neutron Capture Therapy (BNCT) dose optimization for Esophageal Cancer using Particle and Heavy Ion Transport Code System (PHITS) ver. 3.35

Cahyani, Putri Nur, Tirono, Mokhamad ORCID: https://orcid.org/0000-0001-8933-4725, Sardjono, Yohannes, Triatmoko, Isman Mulyadi, Sutrisna, Gede, Nugroho, Fendi, Nuraeni, Nunung and Prasetio, Heru (2025) Boron Neutron Capture Therapy (BNCT) dose optimization for Esophageal Cancer using Particle and Heavy Ion Transport Code System (PHITS) ver. 3.35. Jurnal Teknologi Reaktor Nuklir Tri Dasa Mega, 27 (2). pp. 105-115. ISSN 2527-9963

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Abstract

Esophageal cancer is a type of cancer that has a globally high incidence and mortality rate. Boron Neutron Capture Therapy (BNCT) is a promising radiation therapy method in esophageal cancer treatment due to its ability to deliver high doses selectively to tumor tissue with minimal impact on surrounding healthy tissue. This study aims to optimize BNCT dose distribution, evaluate the irradiation time, and determine the most effective irradiation direction in esophageal cancer. Simulations in this study were carried out using PHITS version 3.35 to model the geometry of esophageal cancer, surrounding organs, and radiation sources used. The phantom represented an ORNL adult male with a 24,69 cm2 tumor. The neutron source came from an accelerator with a 30 MeV proton beam. The boron concentrations analyzed in the cancer tissue were 110, 125, and 140 μg/g. Irradiation from the posterior (PA) direction with a boron concentration of 140 μg/g showed the most optimal BNCT therapy results, with an irradiation time of 15.78 minutes. This technique is capable of delivering an effective dose to the cancerous tissue without exceeding the tolerance limits of the surrounding healthy organs, making it safe for use

Item Type:	Journal Article
Keywords:	BNCT; PHITS; dosimetry; esophageal cancer; radiation direction
Subjects:	02 PHYSICAL SCIENCES > 0299 Other Physical Sciences > 029901 Biological Physics
Divisions:	Faculty of Mathematics and Sciences > Department of Physics
Depositing User:	Dr. Mokhamad Tirono
Date Deposited:	05 Jun 2026 10:19

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