The role of BMP4 in adipose-derived stem cell differentiation: A minireview

Setiawan, Abdul Malik, Kamarudin, Taty Anna and Ghafar, Norzana Abd (2022) The role of BMP4 in adipose-derived stem cell differentiation: A minireview. Frontiers in Cell and Developmental Biology, 10. pp. 1-8. ISSN 2296-634X

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Abstract

Bone morphogenetic protein 4 (BMP4) is a member of the transforming growth factor beta (TGF-β) superfamily of cytokines responsible for stem cells’ commitment to differentiation, proliferation, and maturation. To date, various studies have utilized BMP4 as a chemical inducer for in vitro differentiation of human mesenchymal stem cells (MSCs) based on its potential. BMP4 drives in vitro differentiation of ADSC via TGF-β signaling pathway by interactions with BMP receptors leading to the activation of smad-dependent and smad-independent pathways. The BMP4 signaling pathways are regulated by intracellular and extracellular BMP4 antagonists. Extracellular BMP4 antagonist prevents interaction between BMP4 ligand to its receptors, while intracellular BMP4 antagonist shutdowns the smad-dependent pathways through multiple mechanisms. BMP4 proved as one of the popular differentiation factors to induce ADSC differentiation into cell from mesodermal origin. However, addition of all-trans retinoic acid is also needed in trans-differentiation of ADSC into ectodermal lineage cells. Suggesting that both BMP4 and RA signaling pathways may be necessary to be activated for in vitro trans-differentiation of ADSC.

Item Type:	Journal Article
Keywords:	adsc; stem cell; differentiation
Subjects:	06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060103 Cell Development, Proliferation and Death
Divisions:	Faculty of Medical and Health Sciences > Department of Medical Education
Depositing User:	dr. Abdul Malik Setiawan
Date Deposited:	30 Jun 2026 08:08

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