Fenofibrate attenuates peripheral neuropathic pain by suppressing neuroinflammation in the anterior cingulate cortex

Ardianto, Chrismawan, Kardana, Ni Putu Irma Mayani Putri, Anggraini, Dhea, Pramesthi, Anak Agung Istri Evinia, Aliyah, Alma Nuril ORCID: https://orcid.org/0009-0009-8990-5570, Sumartha, I Nengah Budi, Budiatin, Aniek Setiya, Samirah, Samirah, Shinta, Dewi Wara, Luckanagul, Jittima Amie, Rahmadi, Mahardian and Khotib, Junaidi (2026) Fenofibrate attenuates peripheral neuropathic pain by suppressing neuroinflammation in the anterior cingulate cortex. Pharmacia, 73 (-). pp. 1-8. ISSN 0428-0296

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Abstract

Background: Chemotherapy-induced neuropathy is a frequent complication of cancer treatment and significantly reduces patient quality of life. Neuroinflammatory processes in the anterior cingulate cortex (ACC) play a critical role in the modulation of pain sensitivity. Fenofibrate has demonstrated neuroprotective properties and has been proposed as a potential therapeutic agent for the management of peripheral neuropathy. Materials and methods: A total of 20 male BALB/c mice were divided into four groups (five per group): control, neuropathy (oxaliplatin, 3 mg/kg), neuropathy + fenofibrate (150 mg/kg), and neuropathy + fenofibrate (300 mg/kg). A behavioral test using von Frey filaments was used to assess mechanical allodynia. mRNA expression of ionized calcium-binding adapter molecule 1 (IBA-1), tumor necrosis factor-alpha (TNF-α), and caspase-3 in the ACC was measured using RT-qPCR. Results: Fenofibrate at doses of 150 and 300 mg/kg improved the mechanical withdrawal threshold, followed by significant alterations in the mRNA expression of IBA-1, TNF-α, and caspase-3. Conclusion: Fenofibrate ameliorates chemotherapy-induced neuroinflammation and neuronal apoptosis in the ACC.

Item Type:	Journal Article
Keywords:	anterior cingulate cortex, cancer, chemotherapy, fenofibrate, peripheral neuropathy
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Alma Nuril Aliyah
Date Deposited:	16 Jul 2026 04:24

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