Cinnamomum burmanii leaf extract potential on hematological assessment of rats exposed to polystyrene nanoplastics

Pramudya, Manikya, Soepriandono, Hari, Nurbani, Farah Annisa, Safitri, Maya, Dewi, Firli Rahmah Primula, Al-Hanif, Arghi Kinanthya Rif’atullah, Susilo, Raden Joko Kuncoroningrat, Aunurohim, Aunurohim, Muchtaromah, Bayyinatul ORCID: https://orcid.org/0000-0001-9968-8295 and Hayati, Alfiah (2025) Cinnamomum burmanii leaf extract potential on hematological assessment of rats exposed to polystyrene nanoplastics. Research J. Pharm. and Tech., 18 (4). pp. 1573-1578. ISSN 0974-360X

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Abstract

The growth of the plastic industry alongside inadequate management of plastic waste has resulted in plastic pollution. Nanoplastic particles can be toxic and induce oxidative stress. This research explored the ability of Cinnamomum burmanii leaf extract to mitigate hematological alterations induced by exposure to low-dose nanoplastics polystyrene (NPs) in male albino rats. Normal control and negative control groups were administrated with aquadest and NPs solution (10µL/kg) for 14 days respectively, followed by aquadest for the next 21 days. Groups 3, 4, and 5 received a combined treatment of NPs for 14 days and extract for 21 days (100, 200, and 400mg/kg). Each group consists of five rats. Animal treatments were administered through oral gavage. Then, the hematological parameters were analyzed. The results revealed that exposure to NPs caused a significant elevation in lymphocyte counts and a decrease in monocytes, red blood cells (RBC), hemoglobin (Hb), and hematocrit (Ct). Nevertheless, there was no significant impact observed on white blood cells (WBC), granulocytes, or platelet counts. Within the groups treated with Cinnamomum burmanii leaf extract, a reduction in lymphocyte and WBC counts was observed, alongside an increase in monocyte counts. However, there was no significant increase noted in red RBC, Hb, Ct, or platelet counts. Cinnamomum burmanii leaf extract may hold promise in improving the hemodynamic profile in bodies exposed to NPs.

Item Type:	Journal Article
Keywords:	cinnamomum burmanii; hematology; immunology; nanoplastics; rat.
Subjects:	06 BIOLOGICAL SCIENCES > 0606 Physiology
Divisions:	Graduate Schools > Magister Programme > Graduate School of Biology
Depositing User:	Bayyinatul Muchtaromah
Date Deposited:	21 Jul 2026 11:18

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