Hepatoprotective effects of schleichera oleosa leaf extract on TGF-β expression and liver fibrosis in CCl₄-induced rat model

Griana, Tias Pramesti ORCID: https://orcid.org/0000-0002-2974-0884, Holil, Kholifah, Andrean, Vicki, Aathifah, Aathifah and Listiyana, Anik ORCID: https://orcid.org/0000-0001-6476-2977 (2026) Hepatoprotective effects of schleichera oleosa leaf extract on TGF-β expression and liver fibrosis in CCl₄-induced rat model. el-Hayah. ISSN e-ISSN: 2460-7207, p-ISSN: 2086-0064

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Abstract

CCL4 exposure on rat resulted hepatocyte cell necrosis and activated macrophages to produce TGF-β which induced liver fibrosis. Kesambi (Schleichera oleosa (Lour.) Oken) plants have active compounds that affect the inflammatory process. The purpose of this study was to determine the effects of methanol leaf extracts from Kesambi on TGF-β levels and histological feature of liver in rat exposed to CCL4. Thirty male Wistar rat were divided into 5 groups, K- (injected with corn oil i.p), K+ (injected with CCL4 0,5µl/grb.w. i.p, 2x a week), and the treatment group injected with CCL4 0,5µl/grb.w. i.p, 2x a week and administrated methanol leaf extracts from kesambi dose 200mg/kgb.w. (P1), 400mg/kgb.w. (P2), and 600mg/kgb.w. (P3), everyday. After 6 weeks, the rats were dissected. Liver was taken for TGF-β levels measurement by flow cytometry, necrotizing hepatocyte cells calculation and fibrosis score by METAVIR method. TGF-β level of P3 (4,21%) was significantly different (p

Item Type:	Journal Article
Keywords:	CCL4, kesambi, (Schleichera oleosa (Lour.) Oken), TGF-β, fibrosis
Subjects:	06 BIOLOGICAL SCIENCES > 0608 Zoology > 060807 Animal Structure and Function
Divisions:	Faculty of Medical and Health Sciences > Department of Medical Education
Depositing User:	Kholifah Holil
Date Deposited:	27 Jul 2026 11:29

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