Impaired Th1 responses in patients with acute exacerbations of COPD are improved with PD-1 blockade

Tan, Dino B.A. and Teo, Teck-Hui and Setiawan, Abdul Malik and Ong, Nathanael E. and Zimmermann, Maja and Hsu, Alan Chen-Yu and Wark, Peter A.B. and Moodley, Yuben P. (2018) Impaired Th1 responses in patients with acute exacerbations of COPD are improved with PD-1 blockade. Clinical Immunology, 188. pp. 64-66. ISSN 1521-6616

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Full text available at: http://doi.org/10.1016/j.clim.2017.12.007

Abstract

Poor T-cell function is implicated in susceptibility to infections in COPD patients.

Proportion of circulating PD-1+ CD4+ T-cells is elevated in AECOPD patients.

Systemic inflammation is associated with elevated proportion of PD-1+ CD4+ T-cells.

PD-1 blockade increased the production of IFNγ, TNF, IL-6 and IL-10 by anti-CD3-induced PBMC.

Item Type: Journal Article
Keywords: acute exacerbation of COPD; AECOPD; chronic obstructive pulmonary; COPD; PD-1; T-cell;
Divisions: Faculty of Medical and Health Sciences > Department of Medical Education
Depositing User: Faizuddin Harliansyah
Date Deposited: 05 Jun 2018 03:32

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