Impaired Th1 responses in patients with acute exacerbations of COPD are improved with PD-1 blockade

Tan, Dino B.A., Teo, Teck-Hui, Setiawan, Abdul Malik, Ong, Nathanael E., Zimmermann, Maja, Hsu, Alan Chen-Yu, Wark, Peter A.B. and Moodley, Yuben P. (2018) Impaired Th1 responses in patients with acute exacerbations of COPD are improved with PD-1 blockade. Clinical Immunology, 188. pp. 64-66. ISSN 1521-6616

Full text not available from this repository.

Abstract

Poor T-cell function is implicated in susceptibility to infections in COPD patients.

Proportion of circulating PD-1+ CD4+ T-cells is elevated in AECOPD patients.

Systemic inflammation is associated with elevated proportion of PD-1+ CD4+ T-cells.

PD-1 blockade increased the production of IFNγ, TNF, IL-6 and IL-10 by anti-CD3-induced PBMC.

Item Type:	Journal Article
Keywords:	acute exacerbation of COPD; AECOPD; chronic obstructive pulmonary; COPD; PD-1; T-cell;
Divisions:	?? JDok ??
Depositing User:	Faizuddin Harliansyah
Date Deposited:	05 Jun 2018 10:32

Downloads

Origin of downloads

Actions (login required)

View Item