Parasitemia Induces High Plasma Levels of Interleukin-17 (IL-17) and Low Levels of Interleukin-10 (IL-10) and Transforming Growth Factor-ß (TGF-ß) in Pregnant Mice Infected with Malaria

Rahmah, Zainabur and Sasmito, Sujarot Dwi and Siswanto, Budi and Sardjono, Teguh Wahju and Fitri, Loeki Enggar (2015) Parasitemia Induces High Plasma Levels of Interleukin-17 (IL-17) and Low Levels of Interleukin-10 (IL-10) and Transforming Growth Factor-ß (TGF-ß) in Pregnant Mice Infected with Malaria. Malaysian Journal of Medical Sciences, 22 (3). pp. 25-32. ISSN 2180-4303

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Abstract

Background: During pregnancy, the balanced dominance of the T helper17 response shifts to a Th2 response that is characterised by the production of IL-10, following the completion of the implantation process. Transforming growth factor-β (TGF-β) expression is associated with the completion of trophoblast invasion and placental growth. This study assessed the effect of malaria infection on the levels of IL-17, IL-10, and TGF-β in the plasma of pregnant mice with malaria.

Methods: Seventeen pregnant BALB/C mice were divided into two groups: mice infected with Plasmodium berghei (treatment group) and uninfected mice (control group). The mice were sacrificed on day 18 post-mating. Parasitemia was measured by Giemsa staining. The levels of IL-17, IL-10, and TGF-β were measured by ELISA.

Results: Using independent t test, the IL-17 levels in the treatment group were higher than those in the control group (= = 0.040). The IL-10 levels in the treatment group were lower than those in the control group (= = 0.00). There was no significant difference in the TGF-β levels (= = 0.055) between two groups. However, using SEM analysis the degree of parasitemia decreased the plasma TGF-β levels (tcount = 5.148; ≥ ttable = 1.96). SEM analysis showed that a high degree of parasitemia increased the IL-17 levels and decreased the IL-10 and TGF-β levels.

Conclusion: Malaria infection during pregnancy interferes with the systemic balance by increasing the IL-17 levels and decreasing the IL-10 and TGF-β levels.

Item Type: Journal Article
Keywords: Plasmodium berghei; pregnancy; parasitemia; interleukin 17; interleukin 10; transforming growth factor-β
Divisions: Faculty of Medical and Health Sciences > Department of Medical Education
Depositing User: Faizuddin Harliansyah
Date Deposited: 06 Jun 2018 21:05

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