In Silico Study of Avocado (Persea americana Mill.) Seed Compounds Against PBP2a Receptor on Staphylococcus aureus

Kusuma, Meike Tyas and Susilowati, Retno (2018) In Silico Study of Avocado (Persea americana Mill.) Seed Compounds Against PBP2a Receptor on Staphylococcus aureus. Bioinformatics and Biomedical Research Journal, 1 (2). pp. 45-48. ISSN 2620-3324

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Abstract

The nosocomial infection causes 1,4 million mortality every day in the world. International Nosocomial Infection Control Consortium (INICC) data shows that 84,4% nosocomial infection is caused by S. aureus that can cause skin infection. Avocado (P. americana) seed has been reported as an antibacterial agent and used for dermatological applications. This research was aimed to know the potential of antibacterial activity of ethanolic extract of avocado seed in silico study. The in silico test used molecular docking method with PyRx software between PBP2a as receptor and phytochemical compounds in avocado seed as a ligand. The result showed that rutin compound had the best potential to bind PBP2a (binding affinity: -18,2 kcal/mol). Thus, phytochemical active compounds in avocado seed can be recommended as an antibacterial drug and can increase the number of fibroblast cells caused by S. aureus.

Item Type:	Journal Article
Keywords:	In silico; avocado seed; PBP2a; Staphylococcus aureus
Subjects:	06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060102 Bioinformatics 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060502 Infectious Agents 06 BIOLOGICAL SCIENCES > 0606 Physiology > 060603 Animal Physiology - Systems
Divisions:	Faculty of Mathematics and Sciences > Department of Biology
Depositing User:	Faizuddin Harliansyah
Date Deposited:	18 Feb 2019 15:14

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